Isonipecotamide Struktur

Piperidin-4-carboxamid

Bezeichnung:Piperidin-4-carboxamid

CAS-Nr39546-32-2

Englisch Name:Isonipecotamide

CBNumberCB3411759

SummenformelC6H12N2O

Molgewicht128.17

MOL-Datei39546-32-2.mol

Synonyma

Piperidin-4-carboxamid

Piperidin-4-carboxamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	145-148 °C(lit.)
Siedepunkt	237.61°C (rough estimate)
Dichte	1.0754 (rough estimate)
Brechungsindex	1.4880 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Sparingly), Methanol (Slightly)
pka	16.48±0.20(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to light yellow
Wasserlöslichkeit	Soluble in water.
Sensitive	Hygroscopic
BRN	112554
Stabilität	Hygroscopic
InChIKey	DPBWFNDFMCCGGJ-UHFFFAOYSA-N
LogP	-0.88
CAS Datenbank	39546-32-2(CAS DataBase Reference)
EPA chemische Informationen	4-Piperidinecarboxamide (39546-32-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39-36
WGK Germany	3
Hazard Note	Irritant
TSCA	Yes
HS Code	29339900

Gefahreninformationscode (GHS)

Isonipecotamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Verwenden
Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.
Verwenden
Reactant for synthesis of:• ;Survival motor neuron (SMN) protein modulators1• ;Diaminotriazine hNav1.7 inhibitors2• ;Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase3• ;Orally available naphthyridine protein kinase D inhibitors4• ;Phosphodiesterase 5 inhibitors5Reactant for identification of small molecular inhibitors of importin-β mediated nublear import6
Verwenden
Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.
Application
Isonipecotamide is an important substrate for organic synthesis reactions and can be used to prepare a wide range of inhibitors:
(1) Dual inhibitors of thrombin and cholinesterase with therapeutic potential for Alzheimer's disease^[1].
(2) 5-HT receptor inhibitors, based on Isonipecotamide synthesised piperidine carboxamide derivatives showing signs of decreasing 5-HT levels alone while increasing dopamine levels, with antidepressant drug effects^[2].
(3) Reversible inhibitors of coagulation factor Xa (fXa) and thrombin (thr) (cmpds 1-3), which have the ability to impede the infection of VERO cells with SARS-CoV-2, with cmpds3 showing a significant inhibitory effect on SARS-CoV-2 infection (~30%) at lower concentrations (3-50 μM)^[3].
Definition
ChEBI: 4-Piperidine carboxamide is a piperidinecarboxamide.
Einzelnachweise
[1] ROSA PURGATORIO. First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.[J]. Molecules, 2021. DOI:10.3390/molecules26175208.
[2] SHAMIM AKHTAR. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.[J]. Pakistan journal of pharmaceutical sciences, 2012.
[3] FLAVIO DE MAIO. Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection.[J]. Viruses-Basel, 2022. DOI:10.3390/v14081730.

Isonipecotamide Upstream-Materialien And Downstream Produkte

Piperidin-4-carboxamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

39546-32-2, Isonipecotamide Verwandte Suche:

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