Piperazindihydrochlorid

Bezeichnung:Piperazindihydrochlorid

CAS-Nr142-64-3

Englisch Name:PIPERAZINE DIHYDROCHLORIDE

CBNumberCB0264741

SummenformelC4H12Cl2N2

Molgewicht159.06

MOL-Datei142-64-3.mol

Synonyma

Piperazindihydrochlorid

Piperazindihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	320°C(dec.)(lit.)
Siedepunkt	262.01°C (rough estimate)
Dichte	1.3011 (rough estimate)
Brechungsindex	1.6300 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Water
Aggregatzustand	White crystalline solid
Farbe	White to Off-White
InChI	InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H
InChIKey	CVVIJWRCGSYCMB-UHFFFAOYSA-N
SMILES	C1NCCNC1.Cl.Cl
LogP	-1.171 (est)
CAS Datenbank	142-64-3(CAS DataBase Reference)
EPA chemische Informationen	Piperazine dihydrochloride (142-64-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42/43
S-Sätze:	22-26-36/37
OEB	B
OEL	TWA: 5 mg/m3
RTECS-Nr.	TL4025000
F	3-10
HS Code	2933599550
Giftige Stoffe Daten	142-64-3(Hazardous Substances Data)
Toxizität	mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967.

Gefahreninformationscode (GHS)

PIPERAZINE DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
In the manufacture of fibers, pharmarceuticals, and insecticides.
Verwenden
It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.
Verwenden
Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
Allgemeine Beschreibung
White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reaktivität anzeigen
PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.
mögliche Exposition
Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
Carcinogenicity
Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.
läuterung methode
Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
Inkompatibilitäten
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.

PIPERAZINE DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Piperazindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

142-64-3, PIPERAZINE DIHYDROCHLORIDE Verwandte Suche:

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