4-Bromo-2-methoxyphenol

Bezeichnung:4-Bromo-2-methoxyphenol

CAS-Nr7368-78-7

Englisch Name:4-Bromo-2-methoxyphenol

CBNumberCB8225575

SummenformelC7H7BrO2

Molgewicht203.03

MOL-Datei7368-78-7.mol

4-Bromo-2-methoxyphenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	34-37 °C (lit.)
Siedepunkt	129-132°C 12mm
Dichte	1.585±0.06 g/cm3(Predicted)
Flammpunkt	>230 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform, Methanol
pka	9.40±0.18(Predicted)
Aggregatzustand	Low Melting Solid or Crystalline Solid
Farbe	Colorless to white to pale brown
Wasserlöslichkeit	Slightly soluble in water.
BRN	2045286
InChI	InChI=1S/C7H7BrO2/c1-10-7-4-5(8)2-3-6(7)9/h2-4,9H,1H3
InChIKey	WHSIIJQOEGXWSN-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(Br)C=C1OC
CAS Datenbank	7368-78-7(CAS DataBase Reference)
NIST chemische Informationen	4-Bromoguaiacol(7368-78-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29095000
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

4-Bromo-2-methoxyphenol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Verwenden
4-Bromo-2-methoxyphenol is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.A. Schoenberg; R. F. Heck. Palladium-catalyzed formylation of aryl, heterocyclic, and vinylic halides. J. Am. Chem. Soc. 1974, 96 (25), 7761-7764.Joel S. Freundlich; Howard E. Landis. An expeditious aqueous Suzuki-Miyaura method for the arylation of bromophenols. Tetrahedron Letters. 2006, 47(25), 4275-4279.
Synthese

90-05-1

7368-78-7

General procedure for the synthesis of 4-bromo-2-methoxyphenol from guaiacol: NBu4Br3 (1.0 eq.) was dissolved in CH2Cl2 (ca. 5 mL/mmol NBu4Br3), which was immediately added to a CH2Cl2 solution (ca. 5 mL/mmol guaiacol) of guaiacol (1.0 eq.). The reaction mixture was stirred at 23 °C for 2 hours. Subsequently, the solvent was removed under reduced pressure (12 mbar, 40 °C). Water (5.0 mL) was added to the residue and the aqueous layer was extracted with Et2O (3 x 10 mL). The organic layer was separated and dried with MgSO4. The organic solvent was removed under reduced pressure (14 mbar, 40 °C) to give an oily residue, which was finally purified by silica gel column chromatography (SiO2, CH2Cl2).
Einzelnachweise
[1] Synthetic Communications, 2007, vol. 37, # 2, p. 323 - 328
[2] Tetrahedron, 2014, vol. 71, # 1, p. 91 - 101
[3] Tetrahedron Letters, 1995, vol. 36, # 10, p. 1705 - 1708
[4] Synlett, 2012, vol. 23, # 7, p. 1082 - 1084
[5] Journal of the Serbian Chemical Society, 2011, vol. 76, # 5, p. 685 - 692

4-Bromo-2-methoxyphenol Upstream-Materialien And Downstream Produkte

4-Bromo-2-methoxyphenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7368-78-7, 4-Bromo-2-methoxyphenol Verwandte Suche:

Send Inquriy