3,4-Dimethoxyphenol

Bezeichnung:3,4-Dimethoxyphenol

CAS-Nr2033-89-8

Englisch Name:3,4-Dimethoxyphenol

CBNumberCB2354549

SummenformelC8H10O3

Molgewicht154.16

MOL-Datei2033-89-8.mol

Synonyma

3,4-Dimethoxyphenol

3,4-Dimethoxyphenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	79-82 °C (lit.)
Siedepunkt	167°C/14mm
Dichte	1.1690 (rough estimate)
Brechungsindex	1.4740 (estimate)
Flammpunkt	167°C/14mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	10.08±0.18(Predicted)
Aggregatzustand	Fine Crystalline Powder
Farbe	Off-white to light beige
Wasserlöslichkeit	Soluble in water.
Sensitive	Light Sensitive
BRN	1366650
LogP	1.157 (est)
CAS Datenbank	2033-89-8(CAS DataBase Reference)
NIST chemische Informationen	Phenol, 3,4-dimethoxy-(2033-89-8)
EPA chemische Informationen	3,4-Dimethoxyphenol (2033-89-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
F	10
TSCA	Yes
HS Code	29095000

Gefahreninformationscode (GHS)

3,4-Dimethoxyphenol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Red Crystal Powder
Verwenden
A substituted alkynyl phenoxy compound as new synergists in pesticidal compositions.
Verwenden
3,4-Dimethoxyphenol is used in the preparation of 5,6-dimethoxy benzofuranone derivatives and multi-target anti Alzheimer compounds. It is also used in the preparation of 3,4-dimethoxyphenyl-beta-D-glucopyranoside and 4-(but-2-enyloxy)-1,2-dimethoxybenzene. Further, it serves as a precursor for 4H-chromenes synthesis.
Synthese
3,4-Dimethoxyphenol is synthesised using Veratraldehyde as a raw material by chemical reaction. The specific synthesis steps are as follows:
Method (i): To a solution of vertraldehyde (2.11)(5 g,0.03 mole)in glacial acetic acid (30 ml)is added dropwise to a solution of peracetic acid5(15 ml) during 30 min.The temperature of the reaction mixture rises,it is kept at 40-45 by cooling.The reaction mixture is left for 10 hr and then concentrated to about 15 ml in vacuo.The residue is extracted with ether (2 x 20 ml).The ether layer is distilled.The formate ester of 3,4- dimethoxyphenol thus obtained is hydrolysed by refluxing with potassium hydroxide (10 g)in aqueous alcohol (1:4,100 ml)for 1 hr.The reaction mixture is concentrated in vacuo almost to dryness.It is dissolved in water (20 ml),the solution rendered acidic with dilute sulphuric acid and extracted with ether.The ether extract is dried (sodium sulphate)and distilled.The oily residue thus obtained is subjected to column chromatography over silica gel(2 x 30 cm).Elution with benzene gave 3,4-dimethoxyphenol as yellow solid.Yield 3g(65.2%).It is crystallised from benzene as yellow crystalline needles.M.p.78-80(lit.m.p.78-80).

Method (ii): A mixture of veratraldehyde (2.11)(1.66 g,0.01 mole),hydrogen peroxide (30%,2.6 ml,0.023 mole),p-toluenesulphonic acid (6.88 g, 0.036 mole)and methanol (5 ml)is stirred at room temperature.When the reaction is complete (as monitored by TLC)the reaction mixture is diluted with water (50 ml)and extracted with dichloromethane (5 x 50 ml).The extract is dried (anhydrous sodium sulphate)and purified by column chromatography over silica gel(2 x 30 cm).Elution with benzene gave 3,4. dimethoxyphenol as an yellow solid.Yield 1.16 g (75.3%).M.p.78-80.

3,4-Dimethoxyphenol Upstream-Materialien And Downstream Produkte

3,4-Dimethoxyphenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2033-89-8, 3,4-Dimethoxyphenol Verwandte Suche:

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