Natriumbutyrat

Bezeichnung:Natriumbutyrat

CAS-Nr156-54-7

Englisch Name:Sodium Butyrate

CBNumberCB7391358

SummenformelC4H7NaO2

Molgewicht110.09

MOL-Datei156-54-7.mol

Synonyma

Natriumbutyrat

Natriumbutyrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	250-253 °C (lit.)
Dichte	1.324 g/cm3 (30℃)
storage temp.	Store below +30°C.
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Amorphous Powder
Farbe	White
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
BRN	3629439
Stabilität	Stable. Incompatible with strong acids.
InChI	InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChIKey	MFBOGIVSZKQAPD-UHFFFAOYSA-M
SMILES	C(CC)C([O-])=O.[Na+]
LogP	0.777 (est)
CAS Datenbank	156-54-7(CAS DataBase Reference)
NIST chemische Informationen	Sodium butyrate(156-54-7)
EPA chemische Informationen	Butanoic acid, sodium salt (156-54-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-68
S-Sätze:	37/39-26-24/25-36/37
RTECS-Nr.	ET6400000
F	3-10
HS Code	29156000
Giftige Stoffe Daten	156-54-7(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Sodium Butyrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.
Verwenden
Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.
Verwenden
Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.
Definition
ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.
benefits
Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.
Biologische Aktivität
Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.
Biochem/physiol Actions
Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.
Lager
Room temperature
läuterung methode
Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]

Sodium Butyrate Upstream-Materialien And Downstream Produkte

Natriumbutyrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

156-54-7, Sodium Butyrate Verwandte Suche:

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