Buttersure Produkt Beschreibung

Butyric Acid Struktur
107-92-6
  • CAS-Nr.107-92-6
  • Bezeichnung:Buttersure
  • Englisch Name:Butyric Acid
  • Synonyma:Buttersure;n-Butansäure<BR>Ethylessigsäure<BR>1-Propancarbonsäure<BR>Butansäure
    C4;C4A;C4A2;C4A3;butyrate;IMET 3393;FEMA 2221;n-Butyric;Butansαure;n-C3H7COOH
  • CBNumber:CB3459186
  • Summenformel:C4H8O2
  • Molgewicht:88.11
  • MOL-Datei:107-92-6.mol
Buttersure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :−6-−3 °C(lit.)
  • Siedepunkt: :162 °C(lit.)
  • Dichte :0.964 g/mL at 25 °C(lit.)
  • Dampfdichte :3.04 (vs air)
  • Dampfdruck :0.43 mm Hg ( 20 °C)
  • Brechungsindex :n20/D 1.398(lit.)
  • FEMA  :2221 | BUTYRIC ACID
  • Flammpunkt: :170 °F
  • storage temp.  :-20°C
  • pka :4.83(at 25℃)
  • Aggregatzustand :Liquid
  • Wichte :0.960 (20/4℃)
  • Farbe :Clear colorless
  • PH :2.5 (100g/l, H2O, 20℃)
  • Explosionsgrenze :2-12.3%(V)
  • Wasserlöslichkeit :MISCIBLE
  • Merck  :14,1593
  • JECFA Number :87
  • BRN  :906770
  • Stabilität: :Stability Flammable. Incompatible with strong oxidizing agents, aluminium and most other common metals, alkalies, reducing agents.
  • InChIKey :FERIUCNNQQJTOY-UHFFFAOYSA-N
  • CAS Datenbank :107-92-6(CAS DataBase Reference)
  • NIST chemische Informationen :Butanoic acid(107-92-6)
  • EPA chemische Informationen :Butanoic acid(107-92-6)
Sicherheit
  • Kennzeichnung gefährlicher :C,Xi
  • R-Sätze: :34
  • S-Sätze: :26-36-45
  • RIDADR  :UN 2820 8/PG 3
  • WGK Germany  :1
  • RTECS-Nr. :ES5425000
  • F  :13
  • Selbstentzündungstemperatur :824 °F
  • Hazard Note  :Irritant
  • TSCA  :Yes
  • HS Code  :2915 60 19
  • HazardClass  :8
  • PackingGroup  :III
  • Giftige Stoffe Daten :107-92-6(Hazardous Substances Data)
  • Toxizität :LD50 orally in rats: 8.79 g/kg (Smyth)

Butyric Acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD FARBLOSE öLIGE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
  • CHEMISCHE GEFAHREN Mittelstarke Säure. Reagiert mit Basen und starken Oxidationsmitteln. Greift viele Metalle an.
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt (ACGIH 2005).
    MAK nicht festgelegt (DFG 2005).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation der Dämpfe.
  • INHALATIONSGEFAHREN Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz verätzt die Augen, die Haut und die Atemwege.
  • LECKAGE Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste vorsichtig mit Natronkalk neutralisieren. Dann mit viel Wasser wegspülen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
  • R-Sätze Betriebsanweisung: R34:Verursacht Verätzungen.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  • Aussehen Eigenschaften C4H8O2; farblose, unangenehm stinkende Flüssigkeit.
  • Gefahren für Mensch und Umwelt Reagiert heftig mit starken Oxidationsmitteln, Aluminium und den meisten Metallen und Alkalien.
    Mit Luft Bildung explosionsfähiger Gemische möglich.
    Buttersäure wird von der Haut schnell resorbiert und kann schwere Verätzungen von Haut, Augen (Erblindungsgefahr!) und Schleimhäuten verursachen. Inhalation der Dämpfe kann zu schweren Irritationen der Atmungsorgane führen.
    Schwach wassergefährdender Stoff.
  • Schutzmaßnahmen und Verhaltensregeln Behälter dicht verschlossen, an gut belüftetem Ort lagern.
    Latex- oder Neoprenschutzhandschuhe (nur als kurzzeitiger Spritzschutz).
  • Verhalten im Gefahrfall Mit flüssigkeitsbindendem Material (z. B. Sand, Rench-Rapid) aufnehmen. Als Sondermüll entsorgen.
    Wasser, CO2, Schaum, Pulver.
  • Erste Hilfe Nach Hautkontakt: Mit reichlich Wasser abwaschen. Abtupfen mit Polyethylenglycol 400.
    Nach Augenkontakt: Mit viel Wasser bei geöffnetem Lidspalt mindestens 15 Minuten spülen. Sofort Augenarzt hinzuziehen.
    Nach Einatmen: Frischluft.
    Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen vermeiden (Perforationsgefahr). Sofort Arzt hinzuziehen.
    Nach Kleidungskontakt: Kontaminierte Kleidung sofort ausziehen.
    Ersthelfer: siehe gesonderten Anschlag

  • Sachgerechte Entsorgung Wäßrige Lösungen vorsichtig neutralisieren und in den Sammelbehälter für Salzlösungen geben.
    Größere Mengen als Sondermüll entsorgen.
  • Beschreibung Butyric acid is a carboxylic acid also classified as a fatty acid. It exists in two isomeric forms as shown previously, but this entry focuses on n-butyric acid or butanoic acid. It is a colorless, viscous, rancid-smelling liquid that is present as esters in animal fats and plant oils. Butyric acid exists as a glyceride in butter, with a concentration of about 4%; dairy and egg products are a primary source of butyric acid. When butter or other food products go rancid, free butyric acid is liberated by hydrolysis, producing the rancid smell. It also occurs in animal fat and plant oils.
  • Chemische Eigenschaften Butyric acid (from Greek meaning "butter"), also known under the systematic name butanoic acid, is a carboxylic acid with the structural formula CH3CH2CH2-COOH. Salts and esters of butyric acid are known as butyrates or butanoates. Butyric acid is found in milk, especially goat, sheep and buffalo's milk, butter, Parmesan cheese, and as a product of anaerobic fermentation (including in the colon and as body odor). It has an unpleasant smell and acrid taste, with a sweetish aftertaste (similar to ether). It can be detected by mammals with good scent detection abilities (such as dogs) at 10 ppb, whereas humans can detect it in concentrations above 10 ppm.
    Butyric acid was first observed (in impure form) in 1814 by the French chemist Michel Eugène Chevreul. By 1818, he had purified it sufficiently to characterize it . The name of butyric acid comes from the Latin word for butter, butyrum (or buturum), the substance in which butyric acid was first found.
  • Chemische Eigenschaften Butyric acid is a fatty acid occurring in the form of esters in animal fats. The triglyceride of butyric acid makes up 3% to 4% of butter. When butter goes rancid, butyric acid is liberated from the glyceride by hydrolysis, leading to the unpleasant odor. It is an important member of the fatty acid subgroup called short- chain fatty acids. Butyric acid is a medium-strong acid that reacts with bases and strong oxidants, and attacks many metals.
    The acid is an oily, colorless liquid that is easily soluble in water, ethanol, and ether, and can be separated from an aqueous phase by saturation with salts such as calcium chloride. It is oxidized to carbon dioxide and acetic acid using potassium dichromate and sulfuric acid, while alkaline potassium permanganate oxidizes it to carbon dioxide. The calcium salt, Ca(C4H7O2)2·H2O, is less soluble in hot water than in cold.
    Butyric acid has a structural isomer called isobutyric acid (2-methylpropanoic acid).
  • Chemische Eigenschaften Butyric acid is a combustible, oily liquid with an unpleasant odor. The Odor Threshold is 0.0001 ppm.
  • Chemische Eigenschaften Butyric acid, C3H7COOH, a colorless liquid with an obnoxious odor, occurring in spoiled butter.It miscible with water, alcohol, and ether.It is used in the synthesis of butyrate ester perfume and flavor ingredients and in disinfectants and pharmaceuticals,
  • Chemische Eigenschaften n-Butyric acid has a persistent, penetrating, rancid, butter-like odor and burning, acid taste.
  • Occurrence Normally occurs in butter as a glyceride. It has been reported found in the essential oils of citronella Ceylon, Eucalyptus globules, Araucaria cunninghamii, Lippia scaberrima, Monarda fistulosa, cajeput, Heracleum giganteum, lavender, Hedeoma pulegioides, valerian, nutmeg, hops, Pastinaca sativa, Spanish anise and others. It has been identified in strawberry aroma, apricot, American cranberry, sour cherry, black currants, butter, milk, strawberry jam, cheeses (blue, cheddar, feta, Swiss, Camembert and romano), raspberry, papaya, coffee mutton, beer, rum, bourbon whiskey and cider.
  • History Butyric acid gets its name from the Latin butyrum, or butter. It was discovered by Adolf Lieben (1836–1914) and Antonio Rossi in 1869. Butyric acid is one of the simplest fatty acids.
  • Verwenden Butyric Acid is a fatty acid that is commonly obtained from butter fat. it has an objectionable odor which limits its uses as a food acid- ulant or antimycotic. it is an important chemical reactant in the manufacture of synthetic flavoring, shortening, and other edible food additives. in butter fat, the liberation of butyric acid which occurs during hydrolytic rancidity makes the butter fat unusable. it is used in soy milk-type drinks and candies.
  • Verwenden It is used in plastics as a raw material for the cellulose acetate butyrate (CAB). Other uses of butyric acid are in disinfectants, pharmaceuticals, and feed supplements for plant and animals. Butyric acid derivatives play an important role in plant and animal physiology.
  • Verwenden Butyric acid is used in the preparation of various butyrate esters. Low-molecular-weight esters of butyric acid, such as methyl butyrate, have mostly pleasant aromas or tastes. As a consequence, they find use as food and perfume additives. It is also used as an animal feed supplement, due to the ability to reduce pathogenic bacterial colonization. It is an approved food flavoring in the EU FLAVIS database (number 08.005).
    Due to its powerful odor, it has also been used as a fishing bait additive. Many of the commercially available flavors used in carp (Cyprinus carpio) baits use butyric acid as their ester base; however, it is not clear whether fish are attracted by the butyric acid itself or the substances added to it. Butyric acid was, however, one of the few organic acids shown to be palatable for both tench and bitterling. The substance has also been used as a stink bomb by Sea Shepherd Conservation Society to disrupt Japanese whaling crews, as well as by anti-abortion protesters to disrupt abortion clinics.
  • synthetische Obtained by fermentation of starches and molasses with selective enzymes (Granulo saccharobutyricum); it is subsequently isolated as the calcium salt.
  • Definition ChEBI: A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
  • Vorbereitung Methode Butyric acid is produced by oxidation of butyraldehyde (CH3(CH2)2CHO) or butanol (C4H9OH). It can also be formed biologically by the oxidation of sugar and starches using bacteria.
  • Definition A colorless liquid carboxylic acid. Esters of butanoic acid are present in butter.
  • Vorbereitung Methode Butyric Acid is industrially prepared by the fermentation of sugar or starch, brought about by the addition of putrefying cheese, with calcium carbonate added to neutralize the acids formed in the process. The butyric fermentation of starch is aided by the direct addition of Bacillus subtilis. Salts and esters of the acid are called butyrates or butanoates.
    Butyric acid or fermentation butyric acid is also found as a hexyl ester hexyl butyrate in the oil of Heracleum giganteum (a type of hogweed) and as the octyl ester octyl butyrate in parsnip (Pastinaca sativa); it has also been noticed in skin flora and perspiration.
  • Aroma threshold values Detection: 240 ppb to 4.8 ppm
  • Taste threshold values Taste characteristics at 250 ppm: acidic, sour, cheesy, dairy, creamy with a fruity nuance.
  • Allgemeine Beschreibung A colorless liquid with a penetrating and unpleasant odor. Flash point 170°F. Corrosive to metals and tissue. Density 8.0 lb /gal.
  • Air & Water Reaktionen Water soluble.
  • Reaktivität anzeigen (3R,4S)-1-Benzoyl-3-(1-methoxy-1-methylethoxy)-4-phenyl-2-azetidinone can react with oxidizing agents. Incandescent reactions occur with chromium trioxide above 212°F. Also incompatible with bases and reducing agents. May attack aluminum and other light metals .
  • Hazard Strong irritant to skin and tissue.
  • Health Hazard Inhalation causes irritation of mucous membrane and respiratory tract; may cause nausea and vomiting. Ingestion causes irritation of mouth and stomach. Contact with eyes may cause serious injury. Contact with skin may cause burns; chemical is readily absorbed through the skin and may cause damage by this route.
  • Brandgefahr Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
  • Biotechnological Applications Butyrate is produced as end - product of a fermentation process solely performed by obligate anaerobic bacteria. Fermented Kombucha "tea" includes butyric acid as a result of the fermentation. This fermentation pathway was discovered by Louis Pasteur in 1861.
    The pathway starts with the glycolytic cleavage of glucose to two molecules of pyruvate, as happens in most organisms. Pyruvate is then oxidized into acetyl coenzyme A using a unique mechanism that involves an enzyme system called pyruvate - ferredoxin oxidoreductase. Two molecules of carbon dioxide (CO2) and two molecules of elemental hydrogen (H2) are formed as waste products from the cell.
  • Sicherheitsprofil Moderately toxic by ingestion, skin contact, subcutaneous, intraperitoneal, and intravenous routes. Human mutation data reported. Severe skin and eye irritant. A corrosive material. Combustible liquid. Could react with oxidizing materials. Incandescent reaction with chromium trioxide above 100'. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Sicherheit(Safety) The United States Environmental Protection Agency rates and regulates butyric acid as a toxic substance.
    Personal protective equipment such as rubber or PVC gloves, protective eye goggles, and chemical-resistant clothing and shoes are used to minimize risks when handling butyric acid.
    Inhalation of butyric acid may result in soreness of throat, coughing, a burning sensation and laboured breathing. Ingestion of the acid may result in abdominal pain, shock, and collapse. Physical exposure to the acid may result in pain, blistering and skin burns, while exposure to the eyes may result in pain, severe deep burns and loss of vision.
  • mögliche Exposition In manufacture of butyrate esters, some of which go into artificial flavoring. Incompatibilities: May form explosive mixture with air. Incompatible with sulfuric acid, caustics, ammonia, aliphatic amines; isocyanates, strong oxidizers; alkylene oxides; epichlorohydrin
  • Enzyminhibitor This HDAC inhibitor (FWfree-acid = 88.11 g/mol; CAS 107-92-6; FWNa-salt = 110.09 g/mol; CAS 156-54-7), also known as butanoate (the conjugate base of butanoic acid), is a major colonic lumen metabolite formed by bacterial fermentation of dietary fiber. Butyrate also serves as a critical mediator of inflammatory response in the colon. Its action as a histone deacetylase inhibitor is believed to underlie its ability to suppress colonic inflammation by inhibition of IFN-γ/STAT1 signaling pathways. Discovery of HDAC Inhibition: The discovery of butyrate inhibition of histone deacetylases followed early reports that sodium butyrate halts DNA synthesis, arrests cell proliferation, alters cell morphology and increases or decreases gene expression. This finding was followed by the discovery that n-butyrate causes histone modification in HeLa and Friend erythroleukemic cells and that sodium butyrate inhibits histone deacetylation in cultured cells. Later papers added evidence that butyrate suppresses histone deacetylation, both in vivo and in vitro, leading to accumulation of multi-acetylated forms of histones H3 and H4 and increased DNase I-sensitivity of the associated DNA sequences. HDAC8 action on a histone H4 peptide substrate, for example, is inhibited by sodium butyrate, as is deacetylation of nucleosomal core histones. Effect on Fetal Hemoglobin Production: Intermittent therapy in which butyrate is administered for 4 days, followed by 10-24 days without drug, induces fetal globin gene expression in 9 of every 11 patients, with the mean Hb F in this group increased 7-21 % over the course of 39 weeks. Butyrate is likewise a HDAC inhibition- mediated fetal globin gene inducer in patients with b-thalassemia. Other Actions of Butyrate on Histone Acetylation: Butyrate inhibition of HDAC activity affects the expression of ~2% of mammalian genes. Promoters of butyrate-responsive genes have butyrate response elements, and a model has been proposed in which inhibition of Sp1/Sp3-associated HDAC activity leads to histone hyperacetylation and transcriptional activation of the p21 (Waf1/Cip1) gene, with the latter inhibiting cyclin-dependent kinase 2 activity and thereby arresting cell cycling.
  • Erste Hilfe If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 30 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water or milk. Do not induce vomiting
  • Versand/Shipping UN2820 Butyric acid, Hazard class: 8; Labels: 8—Corrosive material. UN2529 Isobutyric acid, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material
  • läuterung methode Distil the acid, them mix it with KMnO4 (20g/L), and fractionally redistil, discarding the first third of the distillate [Vogel J Chem Soc 1814 1948]. [Beilstein 2 IV 779.]
  • Waste disposal Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Butyric Acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Buttersure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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107-92-6, Butyric Acid Verwandte Suche:
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