Trisodium citrate dihydrate

Bezeichnung:Trisodium citrate dihydrate

CAS-Nr6132-04-3

Englisch Name:Trisodium citrate dihydrate

CBNumberCB9752065

SummenformelC6H9Na3O9

Molgewicht294.1

MOL-Datei6132-04-3.mol

Synonyma

Trinatriumcitrat Dihydrat

2-Hydroxy-1,2,3-propantricarbons?ure Trinatriumsalz Dihydrat

Trisodium citrate dihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C(lit.)
Dichte	1.76
FEMA	3026 \| SODIUM CITRATE
Flammpunkt	173.9 °C
storage temp.	Store at +5°C to +30°C.
Löslichkeit	H₂O: 100 mg/mL
Aggregatzustand	powder
Farbe	white
Geruch (Odor)	Odorless
Säure-Base-Indikators(pH-Indikatoren)	7.5 - 9 at 29.4 g/l at 25 °C
PH	7.0-9.0 (25℃, 50mg/mL in H2O)
Wasserlöslichkeit	720 g/L (25 ºC)
maximale Wellenlänge (λmax)	λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01
Merck	14,8602
BRN	6104939
Stabilität	Stable. Incompatible with bases, reducing agents, oxidizing agents.
InChIKey	NLJMYIDDQXHKNR-UHFFFAOYSA-K
LogP	-1.72
CAS Datenbank	6132-04-3(CAS DataBase Reference)
EPA chemische Informationen	1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate (6132-04-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	37/38-41-36/37/38
S-Sätze:	26-36/37/39-24/25-36
WGK Germany	1
RTECS-Nr.	GE7810000
TSCA	Yes
HS Code	2918 15 00
Toxizität	LD50 orally in Rabbit: > 8000 mg/kg

Gefahreninformationscode (GHS)

Trisodium citrate dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSER FESTSTOFF IN VERSCHIEDENEN FORMEN.
CHEMISCHE GEFAHREN
Schwache Base in wässriger Lösung.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: IIb (nicht festgelegt, aber Informationen vorhanden) (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Atemwege.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste mit viel Wasser wegspülen.
R-Sätze Betriebsanweisung:
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Sodium citrate dihydrate consists of odorless, colorless, monoclinic crystals, or a white crystalline powder with a cooling, saline taste. It is slightly deliquescent in moist air, and in warm dry air it is efflorescent. Although most pharmacopeias specify that sodium citrate is the dihydrate, the USP 32 states that sodium citrate may be either the dihydrate or anhydrous material.
Chemische Eigenschaften
white powder or colourless crystals
Verwenden
Anticoagulant for collection of blood. In photography; as sequestering agent to remove trace metals; as emulsifier, acidulant and sequestrant in foods.
Verwenden
Sodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.
Verwenden
An anticoagulant also used as a biological buffer
Verwenden
Trisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. It used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.
Vorbereitung Methode
Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.
Definition
ChEBI: The dihydrate of trisodium citrate.
Allgemeine Beschreibung
Sodium citrate tribasic dihydrate is the tribasic dihydrate sodium salt of citric acid.
Pharmazeutische Anwendungen
Sodium citrate, as either the dihydrate or anhydrous material, is widely used in pharmaceutical formulations.
It is used in food products, primarily to adjust the pH of solutions. It is also used as a sequestering agent. The anhydrous material is used in effervescent tablet formulations. Sodium citrate is additionally used as a blood anticoagulant either alone or in combination with other citrates such as disodium hydrogen citrate.
Therapeutically, sodium citrate is used to relieve the painful irritation caused by cystitis, and also to treat dehydration and acidosis due to diarrhea.
Biologische Aktivität
Commonly used laboratory reagent
Biochem/physiol Actions
Sodium citrate can act as a buffering agent, resisting changes in pH. Used in blood collection tubes, the citrate chelates calcium ions in blood and thereby disrupts blood clotting. Citrate is a intermediate in the TCA cycle and fatty acid synthesis. Citrate is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA.
Sicherheit(Safety)
After ingestion, sodium citrate is absorbed and metabolized to bicarbonate. Although it is generally regarded as a nontoxic and nonirritant excipient, excessive consumption may cause gastrointestinal discomfort or diarrhea. Therapeutically, in adults, up to 15 g daily of sodium citrate dihydrate may be administered orally, in divided doses, as an aqueous solution to relieve the painful irritation caused by cystitis.
Citrates and citric acid enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citrate- or citric acid-containing products.
Lager
Sodium citrate dihydrate is a stable material. Aqueous solutions may be sterilized by autoclaving. On storage, aqueous solutions may cause the separation of small, solid particles from glass containers.
The bulk material should be stored in an airtight container in a cool, dry place.
läuterung methode
Crystallise the salt from warm water by cooling to 0o. [Beilstein 3 III 1100, 3 IV 1274.]
Inkompatibilitäten
Aqueous solutions are slightly alkaline and will react with acidic substances. Alkaloidal salts may be precipitated from their aqueous or hydro-alcohol solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Other incompatibilities include bases, reducing agents, and oxidizing agents.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic products; oral solutions, suspensions, syrups and tablets; nasal, otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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