Tyramine hydrochloride Struktur

4-Hydroxyphenethylammoniumchlorid

Bezeichnung:4-Hydroxyphenethylammoniumchlorid

CAS-Nr60-19-5

Englisch Name:Tyramine hydrochloride

CBNumberCB7345058

SummenformelC8H12ClNO

Molgewicht173.64

MOL-Datei60-19-5.mol

Synonyma

4-Hydroxyphenethylammoniumchlorid

4-Hydroxyphenethylammoniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	253-255 °C(lit.)
Siedepunkt	269°C/760mmHg
storage temp.	Store below +30°C.
Löslichkeit	H2O: soluble50 mg/ml, clear, colorless to faintly yellow
Aggregatzustand	Crystalline Powder
Farbe	White to almost white
PH	<7 (H2O)
Sensitive	Hygroscopic
Merck	14,9835
BRN	3627058
Stabilität	Hygroscopic
LogP	0.722 (est)
CAS Datenbank	60-19-5(CAS DataBase Reference)
EPA chemische Informationen	Phenol, 4-(2-aminoethyl)-, hydrochloride (60-19-5)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	3
RTECS-Nr.	NL4375000
F	3-8-10
TSCA	Yes
HS Code	29222900

Gefahreninformationscode (GHS)

Tyramine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Off-White to Light Yellow Powder
Occurrence
Tyramine was originally a compound isolated from ergot alkaloids and decaying animal tissue. It has pharmacological effects such as increasing blood pressure and exciting the uterus.
Verwenden
Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods. It is an amino acid that helps regulate blood pressure. Tyramine hydrochloride is a sympathomimetic, the hydrochloride salt of the naturally-occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent but cannot cross the blood-brain barrier.
Application
Tyramine hydrochloride (T-HCl) is a kind of fluorogenic substrate of peroxidase. It is a naturally occurring monoamine derived from tyrosine. Tyramine Hydrochloride has been used:
coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure.
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis.
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification.
Neurotransmitter.
Hazard
Tyramine hydrochloride can cause eye irritation and damage in some persons.It also can cause inflammation of the skin oncontact in some persons.Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis.
Biochem/physiol Actions
Tyramine hydrochloride is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.
Synthese
Tyramine [2-(p-hydroxyphenyl) ethylamine], a significant metabolite of tyrosine, enzymatic synthesis of tyramine was established by two-step biocatalytic reaction. Firstly, l-tyrosine was prepared from raw pyruvate fermentation broth under the catalysis of TPL. Pyruvate fermentation broth was simply centrifuged, and then the supernatant was diluted and used as substrate to produce l-tyrosine. Secondly, l-tyrosine was collected as starting material to synthesize tyramine by immobilized TDC cells from Lactobacillus brevis. Pyridoxal phosphate was the common coenzyme for these two enzymes.
läuterung methode
Crystallise the hydrochloride from EtOH by addition of diethyl ether, or from conc HCl. [Beilstein 3 II 355.]

Tyramine hydrochloride Upstream-Materialien And Downstream Produkte

4-Hydroxyphenethylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60-19-5, Tyramine hydrochloride Verwandte Suche:

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