Mercaptaminhydrochlorid

Bezeichnung:Mercaptaminhydrochlorid

CAS-Nr156-57-0

Englisch Name:Cysteamine hydrochloride

CBNumberCB9337215

SummenformelC2H8ClNS

Molgewicht113.61

MOL-Datei156-57-0.mol

Synonyma

Mercaptaminhydrochlorid

Mercaptaminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	67-71 °C
Siedepunkt	238.5℃[at 101 325 Pa]
Dichte	0.75
Dampfdruck	5.333Pa at 25℃
Brechungsindex	1.6100 (estimate)
storage temp.	2-8°C
Löslichkeit	H₂O: 1 m at 20 °C, clear, colorless
Aggregatzustand	Crystalline Powder or Pellets
Farbe	White
PH	3.3-5.0 (400g/l, H2O, 20℃)
Wasserlöslichkeit	VERY SOLUBLE
Sensitive	Hygroscopic
maximale Wellenlänge (λmax)	λ: 280 nm Amax: ≤0.3
Merck	14,2779
BRN	3590083
Stabilität	Stable, but hygroscopic. Incompatible with strong oxidizing agents.
InChIKey	OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP	-2.14 at 25℃
CAS Datenbank	156-57-0(CAS DataBase Reference)
EPA chemische Informationen	Cysteamine hydrochloride (156-57-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	36/37/39-26-36
RIDADR	UN 3335
WGK Germany	3
RTECS-Nr.	KJ0200000
F	1-3-10-13
TSCA	Yes
HS Code	29309070
Toxizität	LD50 orally in Rabbit: 642 mg/kg

Gefahreninformationscode (GHS)

Cysteamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
Chemische Eigenschaften
White Solid
Verwenden
Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd²⁺ and S^2-.
Verwenden
An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.
Verwenden
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
Allgemeine Beschreibung
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.
Hazard
Toxic by inhalation and ingestion.
Biochem/physiol Actions
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.
Synthese
In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.
läuterung methode
Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride Upstream-Materialien And Downstream Produkte

Mercaptaminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

156-57-0, Cysteamine hydrochloride Verwandte Suche:

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