p-Hydroxyphenylessigsure

Bezeichnung:p-Hydroxyphenylessigsure

CAS-Nr156-38-7

Englisch Name:4-Hydroxyphenylacetic acid

CBNumberCB6314323

SummenformelC8H8O3

Molgewicht152.15

MOL-Datei156-38-7.mol

Synonyma

p-Hydroxyphenylessigsure

p-Hydroxyphenylessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-151 °C(lit.)
Siedepunkt	234.6°C (rough estimate)
Dichte	1.2143 (rough estimate)
Dampfdruck	0.007Pa at 25℃
Brechungsindex	1.4945 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	50g/l
Aggregatzustand	Crystalline Powder
pka	4.50±0.10(Predicted)
Farbe	White to cream or light tan
PH	2.0-2.4 (30g/l, H2O, 20℃)
Wasserlöslichkeit	Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
BRN	1448766
InChIKey	XQXPVVBIMDBYFF-UHFFFAOYSA-N
LogP	0.75 at 25℃
CAS Datenbank	156-38-7(CAS DataBase Reference)
NIST chemische Informationen	Benzeneacetic acid, 4-hydroxy-(156-38-7)
EPA chemische Informationen	Benzeneacetic acid, 4-hydroxy- (156-38-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
WGK Germany	3
RTECS-Nr.	AI2680000
Hazard Note	Irritant
TSCA	Yes
HS Code	29182990

Gefahreninformationscode (GHS)

4-Hydroxyphenylacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.
Verwenden
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
Verwenden
It is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes.
Definition
ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.
synthetische
4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.
4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
Flammability and Explosibility
Not classified
läuterung methode
Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]

4-Hydroxyphenylacetic acid Upstream-Materialien And Downstream Produkte

p-Hydroxyphenylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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