Zolpidem Produkt Beschreibung

Zolpidem Struktur
  • CAS-Nr.82626-48-0
  • Bezeichnung:Zolpidem
  • Englisch Name:Zolpidem
  • Synonyma:
    Ivadal;Niotal;Edluar;CS-1159;ZOLPIDEM;Zoipidem;SL-80.0750;SL-80.0750-23N;Zolpidem (CRM);Stilnoct:Stilnox
  • CBNumber:CB6345253
  • Summenformel:C19H21N3O
  • Molgewicht:307.39
  • MOL-Datei:82626-48-0.mol
Zolpidem physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :189-191°C
  • Dichte :1.12±0.1 g/cm3(Predicted)
  • Flammpunkt: :9℃
  • storage temp.  :Store at RT
  • Löslichkeit :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
  • pka :6.2(at 25℃)
  • Aggregatzustand :solid
  • Farbe :white
  • Wasserlöslichkeit :<10mg/L(room temperature)
  • CAS Datenbank :82626-48-0(CAS DataBase Reference)
  • NIST chemische Informationen :Zolpidem(82626-48-0)
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36/37/38
  • S-Sätze: :26-36
  • RIDADR  :UN1230 - class 3 - PG 2 - Methanol, solution
  • WGK Germany  :3
  • RTECS-Nr. :NJ5109750
  • HS Code  :2933996500

Zolpidem Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Beschreibung Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
  • Chemische Eigenschaften Off-White Solid
  • Originator Synthelabo (France)
  • Verwenden A selective benzodiazepine receptor agonist not related chemically to benzodiazepines
  • Verwenden A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).
  • Definition ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
  • Trademarks Ambien (Sanofi Aventis);Stilnox.
  • Allgemeine Beschreibung Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.
Zolpidem Upstream-Materialien And Downstream Produkte
Downstream Produkte
Zolpidem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
82626-48-0, Zolpidem Verwandte Suche:
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
  • 6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
  • N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
  • 2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
  • 2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
  • N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
  • N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
  • SL-80.0750
  • EDLUAR; SL 80-0750; SL 800750
  • CS-1159
  • Zolpideman(SL 800750)
  • Ivadal
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-α]pyridine-3-acetamide
  • Niotal
  • SL-80.0750-23N
  • Stilnoct:Stilnox
  • Zoipidem
  • N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
  • N,N-Dimethyl-2-[6-methyl-2-p-tolylimidazo[1,2-a]pyridine-3-yl]acetamide
  • Zolpidem tatrate
  • 2-(1,2,6-Trimethyl-1H-indol-3-yl)ethylamine
  • N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]ethanamide
  • Zolpidem CIV (10 mg)
  • N,N,6-triMethyl-2-(4-Methylphenyl)iMidazo[1,2-a]-pyrid
  • Edluar
  • Imidazo[1,2-a]pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-
  • Zolpidem solution
  • Zolpidem (CRM)
  • 82626-48-0
  • C19H21N3O
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotopically Labeled Pharmaceutical Reference Standard
  • Pyridines derivates
  • Zolpidem
  • (intermediate of zolpidem)