Zolpidem

Bezeichnung:Zolpidem

CAS-Nr82626-48-0

Englisch Name:Zolpidem

CBNumberCB6345253

SummenformelC19H21N3O

Molgewicht307.39

MOL-Datei82626-48-0.mol

Zolpidem physikalisch-chemischer Eigenschaften

Schmelzpunkt	189-191°C
Dichte	1.12±0.1 g/cm3(Predicted)
Flammpunkt	9℃
storage temp.	Store at RT
Löslichkeit	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
pka	6.2(at 25℃)
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	<10mg/L(room temperature)
CAS Datenbank	82626-48-0(CAS DataBase Reference)
NIST chemische Informationen	Zolpidem(82626-48-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	NJ5109750
HS Code	2933996500

Gefahreninformationscode (GHS)

Zolpidem Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
Beschreibung
Zolpidem (Item No. 15792) is an analytical reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.
Beschreibung
Zolpidem (Item No. 20648) is a certified reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused. This product is intended for research and forensic applications.
Chemische Eigenschaften
Off-White Solid
Originator
Synthelabo (France)
Verwenden
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines
Verwenden
A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).
Definition
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
Trademarks
Ambien (Sanofi Aventis);Stilnox.
Allgemeine Beschreibung
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.

Zolpidem Upstream-Materialien And Downstream Produkte

82626-48-0, Zolpidem Verwandte Suche:

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