82626-48-0
中文名称
唑吡坦
英文名称
Zolpidem
CAS
82626-48-0
分子式
C19H21N3O
MDL 编号
MFCD00153885
分子量
307.39
MOL 文件
82626-48-0.mol
结构式
基本信息
中文别名
左吡登
唑吡坦
N,N,6-三甲基-2-(4-甲基苯基)咪唑并[1,2-Α]吡啶-3-乙酰胺
N,N,6-三甲基-2-(4-甲基苯基)咪唑并[1,2-A]吡啶-3-乙酰胺
唑吡坦
N,N,6-三甲基-2-(4-甲基苯基)咪唑并[1,2-Α]吡啶-3-乙酰胺
N,N,6-三甲基-2-(4-甲基苯基)咪唑并[1,2-A]吡啶-3-乙酰胺
英文别名
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE HEMITARTRATE
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIMIDINE-3-ACETAMIDE
SL-80.0750
ZOLPIDEM
2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
Ivadal
N，N，6-Trimethyl-2-(4-methylphenyl)imidazo[1，2-α]pyridine-3-acetamide
Niotal
SL-80．0750-23N
Stilnoct：Stilnox
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE HEMITARTRATE
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIMIDINE-3-ACETAMIDE
SL-80.0750
ZOLPIDEM
2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
Ivadal
N，N，6-Trimethyl-2-(4-methylphenyl)imidazo[1，2-α]pyridine-3-acetamide
Niotal
SL-80．0750-23N
Stilnoct：Stilnox
所属类别
药物: 中枢神经系统用药: 精神病治疗药
物理化学性质
| 外观性状 | 结晶，熔点196℃。pKa 6.2。 L-(+)-半酒石酸唑吡坦(Zolpidem Hemitartrate)：(C19H21N3O)2?C4H6O6。[99294-93-6]。无色结晶，无臭。水中溶解度(20℃)：23mg/ml。 |
| 熔点 | 189-191°C |
| 密度 | 1.12±0.1 g/cm3(Predicted) |
| 闪点 | 9℃ |
| 储存条件 | Store at RT |
| 溶解度 | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL |
| 酸度系数(pKa) | 6.2(at 25℃) |
| 形态 | solid |
| 形态 | 固体 |
| 颜色 | white |
| 颜色 | 白色 |
| 水溶解性 | <10mg/L(room temperature) |
| 主要应用 | clinical testing |
| InChI | 1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 |
| InChIKey | ZAFYATHCZYHLPB-UHFFFAOYSA-N |
| SMILES | [n]21c(nc(c2CC(=O)N(C)C)c3ccc(cc3)C)ccc(c1)C |
| CAS 数据库 | 82626-48-0(CAS DataBase Reference) |
| NIST化学物质信息 | Zolpidem(82626-48-0) |
安全数据
| 危险性符号(GHS) |   GHS07,GHS09 |
| 警示词 | 警告 |
| 危险性描述 | H302-H336-H411 |
| 防范说明 | P261-P264-P270-P271-P273-P301+P312 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| 危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS号 | NJ5109750 |
| REACH 注册登记 | Active |
| 海关编码 | 2933996500 |
| 存储类别 | 3 - Flammable liquids |
| 危险性类别 | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
应用领域
用途一
咪唑吡啶类衍生物。选择性地结合于中枢神经系统中的甜ω1-受体亚型，但对ω2-或ω3-受体亚型的亲和性低。用于失眠和焦虑。
制备方法
方法一
化合物(I)和草酰氯及二甲胺作用，可得唑吡坦。
知名试剂公司产品信息
82626-48-0(sigmaaldrich)
Sigma Aldrich