5-Methyl-2-pyridylamin

Bezeichnung:5-Methyl-2-pyridylamin

CAS-Nr1603-41-4

Englisch Name:2-Amino-5-methylpyridine

CBNumberCB0485858

SummenformelC6H8N2

Molgewicht108.14

MOL-Datei1603-41-4.mol

Synonyma

5-Methyl-2-pyridylamin

5-Methyl-2-pyridylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	76-77 °C(lit.)
Siedepunkt	227 °C(lit.)
Dichte	227
Dampfdruck	3.706Pa at 25℃
Brechungsindex	1,524-1,528
Flammpunkt	118°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	1000g/l
Aggregatzustand	Crystalline Powder, Crystals or Flakes
pka	pK1: 7.22(+1) (25°C)
Farbe	White to light yellow
Sensitive	Hygroscopic
BRN	107050
InChIKey	CMBSSVKZOPZBKW-UHFFFAOYSA-N
LogP	1.08
CAS Datenbank	1603-41-4(CAS DataBase Reference)
NIST chemische Informationen	2-Pyridinamine, 5-methyl-(1603-41-4)
EPA chemische Informationen	6-Amino-3-picoline (1603-41-4)

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	23/24/25-36/37/38-25
S-Sätze:	26-36/37/39-45-37/39-28A
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	TJ5141000
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29333999
Toxizität	LD50 orl-rat: 200 mg/kg 85JCAE -,841,86

Gefahreninformationscode (GHS)

2-Amino-5-methylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
light yellow crystalline flakes
Verwenden
2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.
Verwenden
Intermediate.
Sicherheitsprofil
Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.
Synthese
2.2 g (0.377 mol) of trimethylamine are condensed at -10 °C. and added at -5 °C. to a solution of 10.03 g (0.092 mol) of 3-methyl-pyridine 1-oxide in 120 ml of methylene chloride. At this temperature, 7.9 (0.11 mol) of thionyl chloride in 15 ml of methylene chloride is added dropwise in 30 minutes. The temperature during this process is kept below 0 °C. The resulting yellow solution is allowed to thaw and is stirred overnight at room temperature. The solvent is removed in vacuo 35 ml of a 48% strength hydrogen bromide solution and then added. The water is distilled off, and the mixture is then heated to 210 °C. A 48% strength hydrogen bromide solution is continuously added dropwise, and water is distilled. After 8 hours, the reaction is completed according to thin-layer chromatography. The mixture is allowed to cool and is adjusted to pH 9 using a dilute sodium hydroxide solution. The mixture is then extracted four times using ethyl acetate. After filtration, the combined extracts are dried over sodium sulphate and concentrated on the rotary evaporator. 8 g (80.5% of theory) of 2-amino-5-methylpyridine are obtained.
läuterung methode
Crystallise it from acetone. [Beilstein 22/9 V 289.]

2-Amino-5-methylpyridine Upstream-Materialien And Downstream Produkte

5-Methyl-2-pyridylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1603-41-4, 2-Amino-5-methylpyridine Verwandte Suche:

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