3-(5H-Dibenzo[a,d]cyclohepten-5-yliden)propyl(dimethyl)ammoniumchlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Cyclobenzaprine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Beschreibung

  Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (K_is = 25, 60, and 6 nM for M₁, M₂, and M₃, respectively), serotonin 5-HT₂ receptors (K_is = 56 and 330 nM for 5-HT_2C and 5-HT_2B, respectively), and histamine H₁ receptor (IC₅₀ = 20 nM).

• Chemische Eigenschaften

  Crystalline Solid

• Originator

  Flexeril,Merck Sharp andDohme,US,1977

• Verwenden

  Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

• Verwenden

  Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.

• Verwenden

  Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).

• Definition

  ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

• Manufacturing Process

  In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

• Trademarks

  Flexeril (McNeil).

• Therapeutic Function

  Muscle relaxant

• Allgemeine Beschreibung

  Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of?noradrenaline. It is used to treat neck,?back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

• Einzelnachweise

  [1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
  [2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
  [3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.

Cyclobenzaprine hydrochloride Upstream-Materialien And Downstream Produkte

3-(5H-Dibenzo[a,d]cyclohepten-5-yliden)propyl(dimethyl)ammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(329)Suppliers

6202-23-9, Cyclobenzaprine hydrochloride Verwandte Suche: