Phenforminhydrochlorid

Bezeichnung:Phenforminhydrochlorid

CAS-Nr834-28-6

Englisch Name:Phenformin hydrochloride

CBNumberCB2280910

SummenformelC10H16ClN5

Molgewicht241.72

MOL-Datei834-28-6.mol

Synonyma

Phenforminhydrochlorid

Phenforminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	175-178°C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	>=10 g/100 mL at 21 ºC
CAS Datenbank	834-28-6(CAS DataBase Reference)
EPA chemische Informationen	Phenformin hydrochloride (834-28-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	DU2200000
HS Code	29252900
Toxizität	LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)

Gefahreninformationscode (GHS)

Phenformin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
It is an anti-diabetic drug from the biguanide class.
Verwenden
erectile dysfunction therapy
Trademarks
DBI (Ciba-Geigy).
Allgemeine Beschreibung
White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Brandgefahr
Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.
Sicherheitsprofil
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Phenformin hydrochloride Upstream-Materialien And Downstream Produkte

Phenforminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

834-28-6, Phenformin hydrochloride Verwandte Suche:

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