N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid

Bezeichnung:N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid

CAS-Nr132-69-4

Englisch Name:Benzydamine hydrochloride

CBNumberCB0204309

SummenformelC19H23N3O.ClH

Molgewicht345.87

MOL-Datei132-69-4.mol

Synonyma

3-[[1-Benzyl-1H-indazol-3-yl]oxy]-N,N-dimethylpropylaminmonohydrochlorid

N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid

N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-153°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
Merck	14,1122
InChIKey	HNNIWKQLJSNAEQ-UHFFFAOYSA-N
CAS Datenbank	132-69-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	NK7875000
HS Code	2933.99.8290
Toxizität	LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)

Gefahreninformationscode (GHS)

Benzydamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
Chemische Eigenschaften
Off-White Solid
Originator
Tantum,Angelini
Verwenden
A nonsteroidal anti-inflammatory with local anesthetic properties.
Verwenden
anticholinergic
Verwenden
A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
Verwenden
Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.
Definition
ChEBI: Benzydamine hydrochloride is a member of indazoles.
Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
Trademarks
Tantum (Angelini Francesco, Italy).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Kontakt-Allergie
It is a nonsteroidal anti-inflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer.
Nebenwirkungen
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
Sicherheitsprofil
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental animal reproductive effects. An eye irritant. A nonsteroidal antiinflammatory analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Benzydamine hydrochloride Upstream-Materialien And Downstream Produkte

N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

132-69-4, Benzydamine hydrochloride Verwandte Suche:

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