Vadimezan

Bezeichnung:Vadimezan

CAS-Nr117570-53-3

Englisch Name:Vadimezan

CBNumberCB5503379

SummenformelC17H14O4

Molgewicht282.29

MOL-Datei117570-53-3.mol

Vadimezan physikalisch-chemischer Eigenschaften

Schmelzpunkt	259-261 °C
Siedepunkt	520.9±50.0 °C(Predicted)
Dichte	1.321±0.06 g/cm3(Predicted)
Dampfdruck	0Pa at 20℃
storage temp.	2-8°C
Löslichkeit	DMSO: 17 mg/mL, soluble
Aggregatzustand	solid
pka	4.21±0.10(Predicted)
Farbe	light brown
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-50/53
S-Sätze:	60-61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS-Nr.	ZD5536200
HS Code	2932.99.7000

Gefahreninformationscode (GHS)

Vadimezan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
DMXAA (117570-53-3) is a STING (Stimulator of Interferon Genes) agonist selective for mouse STING.1,2 Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts.3 Tumor regression induced by DMXAA results from a cascade of cellular events which include disruption of tumor vasculature followed by the release of chemokines which trigger the recruitment of immune cells.4 DMXAA induced expression of IFN-β resulting in a striking expansion of leukemia-specific T cells extending survival in two acute myeloid leukemia models.5
Verwenden
Vadimezan is a drug that displayed vascular-disrupting activity and induced haemorrhagic necrosis and tumour regression in pre-clinical animal models. It is a substrate for the immune adaptor protein STING in mice.
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.
Allgemeine Beschreibung
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.
Biochem/physiol Actions
DMXAA is an apoptosis inducer; anti-vascular.
Lager
Store at +4°C
Einzelnachweise
1) Prantner et al. (2012), 5,6-Dimethylzanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential; J. Biol. Chem., 287 39776 2) Conlon et al. (2013), Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid; J. Immunol., 190 5216 3) Corrales et al. (2015), Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and immunity; Cell Rep., 11 1018 4) Weiss et al. (2017), The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression; Oncoimmunology, 6 e1346765 5) Curran et al. (2016), STING Pathway Activation Stimulates Potent Immunity Against Acute Myeloid Leukemia; Cell Rep., 15 2357

Vadimezan Upstream-Materialien And Downstream Produkte

Vadimezan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

117570-53-3, Vadimezan Verwandte Suche:

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