2-Bromoquinoline

Bezeichnung:2-Bromoquinoline

CAS-Nr2005-43-8

Englisch Name:2-Bromoquinoline

CBNumberCB5428755

SummenformelC9H6BrN

Molgewicht208.05

MOL-Datei2005-43-8.mol

2-Bromoquinoline physikalisch-chemischer Eigenschaften

Schmelzpunkt	44-48 °C
Siedepunkt	115°C/0.3mmHg(lit.)
Dichte	1.564±0.06 g/cm3(Predicted)
Flammpunkt	>110℃
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	soluble in Methanol
pka	0.58±0.40(Predicted)
Aggregatzustand	powder to crystal
Farbe	White to Light yellow
maximale Wellenlänge (λmax)	319nm(EtOH)(lit.)
InChI	InChI=1S/C9H6BrN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
InChIKey	QKJAZPHKNWSXDF-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C=CC=1Br
CAS Datenbank	2005-43-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	20/21/22-36/37/38-41-37/38-22
S-Sätze:	26-36-39-22
WGK Germany	3
HS Code	29339900
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

2-Bromoquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White powder
Synthese

606-43-9

2005-43-8

The general procedure for the synthesis of 2-bromoquinoline from 1-methyl-2-quinolone was as follows: Triphenylphosphine (1186 mg, 4.52 mmol) and dibromoisocyanuric acid (652 mg, 2.27 mmol) were sequentially added to a 50 mL round bottom flask fitted with a magnetic stirrer and a balloon (for pressure equilibrium) under nitrogen protection. The mixture was heated to 115 °C, at which point the dibromoisocyanuric acid reacted vigorously, and the reaction was continued to maintain this temperature for 10 min. Subsequently, 1-methylquinolin-2(1H)-one (239 mg, 1.50 mmol) was added to the reaction system and the temperature of the reaction was raised to 160-170°C for 16 hours. After completion of the reaction, the reaction mixture was dissolved in dichloromethane and alkalized with triethylamine. Purification was carried out by silica gel column chromatography with hexane-ethyl acetate (6:1, v/v) as eluent to finally obtain 2-bromoquinoline (244 mg, 78% yield). 2-bromoquinoline was a yellow oil, and its 1H-NMR (CDCl3) data were as follows: δ 7.51 (1H, d, J = 8.4 Hz), 7.51-8.20 (4H, m), 7.98 ( 1H, d, J = 8.4Hz).
Einzelnachweise
[1] Heterocycles, 2015, vol. 91, # 7, p. 1445 - 1454

2-Bromoquinoline Upstream-Materialien And Downstream Produkte

2-Bromoquinoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2005-43-8, 2-Bromoquinoline Verwandte Suche:

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