Quinclorac

Bezeichnung:Quinclorac

CAS-Nr84087-01-4

Englisch Name:Quinclorac

CBNumberCB3265860

SummenformelC10H5Cl2NO2

Molgewicht242.06

MOL-Datei84087-01-4.mol

Quinclorac physikalisch-chemischer Eigenschaften

Schmelzpunkt	274°C
Siedepunkt	405.4±40.0 °C(Predicted)
Dichte	1.7500
Brechungsindex	1.6100 (estimate)
Flammpunkt	100 °C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	-3.26±0.10(Predicted)
Farbe	Pale Yellow
BRN	7761858
InChIKey	FFSSWMQPCJRCRV-UHFFFAOYSA-N
EPA chemische Informationen	Quinclorac (84087-01-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	43
S-Sätze:	2-24-37
WGK Germany	2
RTECS-Nr.	VB1984000
HS Code	29334900
Giftige Stoffe Daten	84087-01-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Quinclorac Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S2:Darf nicht in die Hände von Kindern gelangen.
S24:Berührung mit der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
Verwenden
Quinclorac is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.
Definition
ChEBI: A quinolinemonocarboxylic acid that is quinoline-8-carboxylic acid in which the hydrogens at positions 3 and 7 have been replaced by chlorines. It is used (particularly as its dimethylamine salt, known as quinclorac-dimethylammonium) as a (rather persisten ) herbicide for the post-emergence control of weeds in rice, grass and turf. It is not approved for use within the European Union.
Pharmakologie
The mechanism of action of quinclorac is controversial. Koo et al. (27) reported that quinclorac inhibited the incorporation of glucose into the cell wall of maize root cells. The synthesis of cellulose as well as some hemicellulose was inhibited at concentrations that inhibited whole plant growth, leading to the conclusion that quinclorac inhibits cell expansion by inhibiting glucose incorporation into the cell wall (27). These authors found that quinclorac inhibited root elongation in sensitive grasses at concentrations that inhibited cell wall biosynthesis. Cell wall biosynthesis in tolerant grasses was much less affected by quinclorac compared with sensitive grasses (28). Grossmann, on the other hand, believes that quinclorac acts as an auxinic herbicide in grasses as well as broadleaf plants, and that its herbicidal effects are due to production of cyanide (which is a byproduct of ethylene biosynthesis) and induction of the plant hormone abscisic acid (29). In this scenario, inhibition of cell wall biosynthesis would be considered a side effect, and not the primary cause of herbicidal injury. Differences in tolerance to quinclorac in this case are solely due to differences in ethylene induction, in that tolerant plants do not respond to quinclorac by synthesizing ethylene (29,30).
Stoffwechsel
Quinclorac has been under development by BASF since 1982, and it has been marketed since 1984, as the herbicide Facet. Synthesis data are not currently available. Absorption and uptake of quinclorac is rapid, with 85% uptake in crabgrass within the first 30 minutes. Although uptake of quinclorac is rapid, translocation is generally poor, especially in sensitive plants. Tolerant species, such as Kentucky bluegrass, tend to transport more of the chemical away from the area of uptake. This may, in part, explain how tolerant plants are less affected by quinclorac. Quinclorac is metabolized very slowly in both sensitive and tolerant grass species. In leafy spurge, themajor metabolite found 7 days after foliar application of quinclorac was a pentosylglucose ester.
In susceptible grasses, early symptoms of quinclorac activity include rapid chlorosis starting at the elongation zone of newly expanding leaves. This is followed by more widespread chlorosis and, eventually, necrosis. On the other hand, quinclorac seems to affect susceptible broadleaf plants as an auxinic herbicide. Symptoms in broadleaf plants begin with induction of ethylene biosynthesis and epinastic bending of shoots and leaves. This is followed by growth inhibition, chlorosis, wilting, and, finally, necrosis.
Toxicity evaluation
Quinclorac is nonflammable and noncorrosive, and it is stable in storage for at least 2 years. Quinclorac is classified as general use, with an oral LD₅₀ > 2.61 g/kg in rats (31).

Quinclorac Upstream-Materialien And Downstream Produkte

Quinclorac Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

84087-01-4, Quinclorac Verwandte Suche:

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