2,3-Dichloroquinoxaline Struktur

2,3-Dichlorchinoxalin

Bezeichnung:2,3-Dichlorchinoxalin

CAS-Nr2213-63-0

Englisch Name:2,3-Dichloroquinoxaline

CBNumberCB5414800

SummenformelC8H4Cl2N2

Molgewicht199.04

MOL-Datei2213-63-0.mol

Synonyma

2,3-Dichlorchinoxalin

2,3-Dichlorchinoxalin physikalisch-chemischer Eigenschaften

Schmelzpunkt	152-154 °C (lit.)
Siedepunkt	325.69°C (rough estimate)
Dichte	1.4994 (rough estimate)
Brechungsindex	1.6400 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Wasserlöslichkeit	Insoluble in water
Löslichkeit	soluble in Chloroform
Aggregatzustand	Needles
pka	-4.78±0.48(Predicted)
Farbe	Off-white to light brown
BRN	126076
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	SPSSDDOTEZKOOV-UHFFFAOYSA-N
CAS Datenbank	2213-63-0(CAS DataBase Reference)
EPA chemische Informationen	2,3-Dichloroquinoxaline (2213-63-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-36/37/39-45-37/39-28A
RIDADR	2811
WGK Germany	3
RTECS-Nr.	VD1720000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29339900
Toxizität	mouse,LD50,intravenous,5600ug/kg (5.6mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03256,

Gefahreninformationscode (GHS)

2,3-Dichloroquinoxaline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2,3-Dichloroquinoxaline (DCQX) can be used as a substrate for nucleophilic aromatic substitution (SNAr) reactions and is a versatile building block for the synthesis of many quinoxaline derivatives. 2,3-Dichloroquinoxaline reacts with 6-aminothiouracil in ethanol/TEA to form 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one. It reacts with cholest-5-en-3-one semicarbazone/thiosemicarbazone to form steriodal cholest-5-en-3-oxazolo and thiazoloquinoxaline.
Chemische Eigenschaften
solid
Verwenden
2,3-Dichloroquinoxaline was used in the synthesis of mono and 2,3-disubstituted quinoxalines. It was used in solid phase synthesis of HPLC chiral stationary phase containing the N,N′-dialkyl-2,3-diaminoquinoxaline group as a linking structure.
Verwenden
2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive a ctivity.
synthetische
To a stirred solution of quinoxaline-2,3(1H,4H)-dione (5.00 g, 1.0 equiv.), POCl3 was added (20 ml) and refluxed at 100 °C for 3h. After completion of the reaction, as indicated by TLC, the reaction mass was distilled under vaccum and quenched with ice cold water. Off white semi solid was formed and is filtered through buchner funnel under vaccum to yield the 2,3-dichloroquinoxaline in excellent yield.

Appearance: off white solid; Yield: 92% (5.64g); ESI-MS: (m/z) calcd. for C8H4Cl2N2: 197.98, found: 199.10 [M+H]+.
Allgemeine Beschreibung
Gray solid. Insoluble in water.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
A halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Brandgefahr
2,3-Dichloroquinoxaline is probably combustible.
läuterung methode
Recrystallise it from *C6H6 and dry it in a vacuum [Cheeseman J Chem Soc 1804 1955, Beilstein 23/7 V 144].

2,3-Dichloroquinoxaline Upstream-Materialien And Downstream Produkte

2,3-Dichlorchinoxalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2213-63-0, 2,3-Dichloroquinoxaline Verwandte Suche:

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