Streptomycinsulfat Produkt Beschreibung

Streptomycin sulfate  Struktur
3810-74-0
  • CAS-Nr.3810-74-0
  • Bezeichnung:Streptomycinsulfat
  • Englisch Name:Streptomycin sulfate
  • Synonyma:Streptomycinsulfat
    as-15;Gerox;Strepto;Strycin;Verstrep;strepcin;strepvet;vetstrep;Strep-sol;agristrep
  • CBNumber:CB4290144
  • Summenformel:C21H41N7O16S
  • Molgewicht:679.65
  • MOL-Datei:3810-74-0.mol
Streptomycinsulfat physikalisch-chemischer Eigenschaften
  • alpha  :-79~-88°(20℃/D)(c=1,H2O)(calculated on the dried basis)
  • Dichte :1.2302 (rough estimate)
  • Brechungsindex :-85 ° (C=1, H2O)
  • storage temp.  :2-8°C
  • Löslichkeit :H2O: 0.1 g/mL, clear
  • Aggregatzustand :powder
  • Farbe :white to off-white
  • PH :pH (100g/l, 25℃) : 4.5~7.0
  • Wasserlöslichkeit :>=0.01 g/100 mL at 18 ºC
  • Merck  :14,8826
  • BRN  :3894995
  • Stabilität: :Stable. Incompatible with strong oxidizing agents.
  • InChIKey :QTENRWWVYAAPBI-YZTFXSNBSA-N
  • CAS Datenbank :3810-74-0
  • EPA chemische Informationen :Streptomycin sulfate (3810-74-0)
Sicherheit

Streptomycin sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften White to off-white powder
  • Verwenden Antibiotic substance produced by aerobic fermentation. Antibacterial (tuberculostatic).
  • Verwenden Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis.
  • Verwenden Triacetine
  • Trademarks Strycin (Bristol-Myers Squibb).
  • Allgemeine Beschreibung An antibacterial. White to light gray or pale buff powder with faint amine-like odor.
  • Air & Water Reaktionen Hygroscopic. Water soluble.
  • Reaktivität anzeigen Streptomycin sulfate is a medicinal amino saccharide.
  • Health Hazard SYMPTOMS: Symptoms of exposure to Streptomycin sulfate include skin rashes, eosinophilia, blood dyscrasias, stomatitis, anaphylactic shock, pruritus, scaling, and fever.
  • Brandgefahr Flash point data for Streptomycin sulfate are not available, however Streptomycin sulfate is probably combustible.
  • Clinical Use Streptomycin sulfate is a white, odorless powder that is hygroscopicbut stable toward light and air. It is freely solublein water, forming solutions that are slightly acidic or nearlyneutral. It is very slightly soluble in alcohol and is insolublein most other organic solvents. Acid hydrolysis yields streptidineand streptobiosamine, the compound that is a combinationof L-streptose and N-methyl-L-glucosamine.
    Streptomycin acts as a triacidic base through the effectof its two strongly basic guanidino groups and the moreweakly basic methylamino group. Aqueous solutions maybe stored at room temperature for 1 week without any lossof potency, but they are most stable if the pH is between 4.5and 7.0. The solutions decompose if sterilized by heating,so sterile solutions are prepared by adding sterile distilledwater to the sterile powder. The early salts of streptomycincontained impurities that were difficult to remove andcaused a histamine-like reaction. By forming a complexwith calcium chloride, it was possible to free the streptomycinfrom these impurities and to obtain a product thatwas generally well tolerated.
    The organism that produces streptomycin, S. griseus, alsoproduces several other antibiotic compounds: hydroxystreptomycin,mannisidostreptomycin, and cycloheximide (q.v.).Of these, only cycloheximide has achieved importance as amedicinally useful substance. The term streptomycin A hasbeen used to refer to what is commonly called streptomycin,and mannisidostreptomycin has been called streptomycin B.Hydroxystreptomycin differs from streptomycin in having ahydroxyl group in place of one of the hydrogen atoms of thestreptose methyl group. Mannisidostreptomycin has a mannoseresidue attached in glycosidic linkage through the hydroxylgroup at C-4 of the N-methyl-L-glucosamine moiety.The work of Dyer et al. to establish the stereochemicalstructure of streptomycin has been completed, and confirmedwith the total synthesis of streptomycin and dihydrostreptomycinby Japanese scientists.
  • Sicherheitsprofil Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Human systemic effects by intraperitoneal route: flaccid paralysis without anesthesia, motor activity changes and pulmonary changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also STREPTOMYCIN and SULFATES.
  • läuterung methode The sulfate is recrystallised from H2O/EtOH, washed with a little EtOH, Et2O and dried in a vacuum. [UV and IR: Grove & Randall Antibiotics Monographs 2 163 1855, Heuser et al. J Am Chem Soc 75 4013 1953, Kuehl et al. J Am Chem Soc 68 1460 1946, Regna et al. J Biol Chem 165 631 1946.] During protein synthesis it inhibits initiation and causes misreading of mRNA [Zierhut et al. Eur J Biochem 98 577 1979, Chandra & Gray Methods Enzymol 184 70 1990]. [Beilstein 18/11 V 82.]
Streptomycin sulfate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Streptomycinsulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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3810-74-0, Streptomycin sulfate Verwandte Suche:
  • Verstrep
  • O-2-Deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-D-streptamine sulfate
  • Strep-sol
  • Streptomyc
  • Streptomycin 2/3 Sulfate
  • 2-[(1S,2R,3S,4S,5R,6S)-5-(diaminomethylideneamino)-2-[(2R,3S,4S,5R)-3-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyl-oxolan-2-yl]oxy-3,4,6-trihydroxy-cyclohexyl]guanidine
  • D-Streptamine, O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3)
  • O-2-Deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-Streptamine sulfate (2:3) salt
  • Streptomycin Sulfate Sterile
  • Streptomycin Sulfate [for Protein Research]
  • STREPTOMYCIN SULFATERESEARCH GRADE
  • Strepto
  • Umbilicaria esculenta
  • StrepoMycin sulfate
  • O-2-deoxy-2-(MethylaMino)-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-forMyl-α-L-lyxofura nosyl-(1-4)-N1,N3-bis(aMinoiMinoMethyl)-D-streptaMine Disulfate
  • StreptoMycin sulfate sterile / oral API
  • StreptoMycin sulphate inject grade
  • Streptomycin sulfate salt,Streptomycini sulfas
  • Streptomycin Sulfate (200 mg)
  • 5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1.fwdarw.)-n,n’-bis(aminoiminomethyl
  • agrimycin17
  • agristrep
  • as-15
  • D-Streptamine,O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1to2)-O-5-deoxy-3-C-formyl-.alpha.-L-lyxofuranosyl-(1to4)-N,N’-bis(aminoiminomethyl)-,sulfate(2:3)(salt)
  • o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1.fwdarw.)-o-d-streptamin
  • phytomycin
  • plantomycin
  • strepcin
  • strep-gran
  • strepsulfat
  • streptomycin,sulfate(2:3)(salt)
  • streptomycinpresentassulphate
  • streptomycinsulfate(2:3)(salt)
  • streptomycinsulphateb.p
  • streptorex
  • strepvet
  • sulfate(2:3)(salt)
  • vetstrep
  • STREPTOMYCINI SULFAS
  • STREPTOMYCIN SESQUISULFATE
  • STREPTOMYCIN SESQUISULFATE HYDRATE
  • STREPTOMYCIN SULFATE
  • STREPTOMYCIN SULFATE (2:3)
  • STREPTOMYCIN SULFATE SALT
  • STREPTOMYCIN SULFATE, STREPTOMYCES SPECIES
  • STREPTOMYCIN SULPHATE
  • o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1->4)-n,n'-bis(aminoiminomethyl)-streptamine sulfate (2:3)
  • N-METHYL-L-GLUCOSAMINIDOSTREPTOSIDO STREPTIDINE SULFATE
  • STREPTOMYCIN SULPHATE ORAL GRADE
  • STREPTOMYCIN SULPHATE ORAL BP 98
  • STREPTOMYCIN SULFATE PLANT CELL CULTURE TESTED
  • STREPTOMYCIN SULFATE CELL CULTURE*TESTED
  • STREPTOMYCIN SULFATE, PH EUR
  • STREPTOMYCIN SULFATE GAMMA-IRRADIATED*MO LECULAR BIO
  • STREPTOMYCIN SULFATE SALT, BIOTECHNOLOGY
  • STREPTOMYCIN SULFATE EMBRYO TESTED
  • STREPTOMYCIN STANDARD SOLUTION*
  • STREPTOMYCIN SULFATE GAMMA-IRRADIATED*CE LL CULTURE