Dihydrostreptomycinsulfat

Bezeichnung:Dihydrostreptomycinsulfat

Englisch Name:Dihydrostreptomycin sulfate

CBNumberCB7182112

SummenformelC21H43N7O16S

Molgewicht681.67

Synonyma

Dihydrostreptomycinsulfat

Dihydrostreptomycinsulfat physikalisch-chemischer Eigenschaften

alpha	D25 -88.5° (1% soln)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, faintly yellow
Aggregatzustand	crystalline
Farbe	white to light yellow
Wasserlöslichkeit	Soluble in water
Merck	13,3201
BRN	3894221
Stabilität	Hygroscopic
EPA chemische Informationen	D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt) (5490-27-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	WK2236000
TSCA	Yes
HS Code	29412030

Gefahreninformationscode (GHS)

Chemische Eigenschaften
White Solid
Originator
Dihydrostrepto,MSD ,US,1948
Verwenden
Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
Verwenden
antibacterial, tuberculostatic
Verwenden
As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
Manufacturing Process
Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
Therapeutic Function
Antibiotic
läuterung methode
It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]