Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat

Bezeichnung:Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat

CAS-Nr1149-23-1

Englisch Name:Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

CBNumberCB4757520

SummenformelC13H19NO4

Molgewicht253.29

MOL-Datei1149-23-1.mol

Synonyma

Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat

Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat physikalisch-chemischer Eigenschaften

Schmelzpunkt	178-183 °C(lit.)
Siedepunkt	351.8±42.0 °C(Predicted)
Dichte	1.104±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in organic solvents.
pka	3.50±0.70(Predicted)
Aggregatzustand	Solid
Farbe	Yellow
maximale Wellenlänge (λmax)	374nm(EtOH)(lit.)
InChI	InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3
InChIKey	LJXTYJXBORAIHX-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O
CAS Datenbank	1149-23-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	2
RTECS-Nr.	US7970100
HS Code	29333990
Toxizität	LD50 oral in dog: > 12gm/kg

Gefahreninformationscode (GHS)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Light green solid
Verwenden
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction.
Verwenden
3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.
Application
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode.
Hazard
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Toxikologie
rat LD50 intraperitoneal >16 gm/kg
mouse LD50 oral >32 gm/kg
mouse LD50 intraperitoneal >30 gm/kg
dog LD50 oral >12 gm/kg
Synthese
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas.
läuterung methode
recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3)

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Upstream-Materialien And Downstream Produkte

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