Androstanolon

Bezeichnung:Androstanolon

CAS-Nr521-18-6

Englisch Name:Stanolone

CBNumberCB9181225

SummenformelC19H30O2

Molgewicht290.45

MOL-Datei521-18-6.mol

Synonyma

Androstanolon

Androstanolon physikalisch-chemischer Eigenschaften

Schmelzpunkt	178-183 °C
alpha	27 º
Siedepunkt	372.52°C (rough estimate)
Dichte	1.0320 (rough estimate)
Brechungsindex	1.4709 (estimate)
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
pka	15.08±0.60(Predicted)
Wasserlöslichkeit	344.3g/L(temperature not stated)
Merck	13,8872
BRN	2056371
InChIKey	NVKAWKQGWWIWPM-ABEVXSGRSA-N
CAS Datenbank	521-18-6(CAS DataBase Reference)
NIST chemische Informationen	Stanolone(521-18-6)
EPA chemische Informationen	Androstan-3-one, 17-hydroxy-, (5.alpha.,17.beta.)- (521-18-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	61-40-39/23/24/25-23/24/25-11
S-Sätze:	53-36/37/39-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	BV8052000

Gefahreninformationscode (GHS)

Stanolone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles. It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy.
Chemische Eigenschaften
White Crystalline Solid
Originator
Neodrol,Pfizer,US,1953
Verwenden
Stanolone is a potent androgenic metabolite of testosterone that It is Controlled substance. It was created for the treatment of muscle wasting disease, and osteoporosis. It is a powerful anabolic steroid, which is similar to the body's naturally produced Dihydrotestosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.
Definition
ChEBI: Stanolone is a 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, a 17beta-hydroxyandrostan-3-one and a 3-oxo-5alpha-steroid. It derives from a hydride of a 5alpha-androstane.
Manufacturing Process
A solution of 1.0 g of 3,17-androstandione in 50 ml of methanol and containing 1 g of selenium dioxide, was allowed to remain in an ice-chest overnight. The formed 3,3-dimethoxyandrostan-17-one was not separated. 1 g of solid potassium hydroxide and 2.5 g of sodium borohydride in 2.5 ml of water were added and the mixture allowed to react at room temperature for 24 hours. The solution was then poured into a large excess of water, extracted with methylene chloride, the organic layer dried and evaporated to a residue. The residue was dissolved in ether, and a small amount of selenium removed by filtration. The ether was boiled off and the organic material dissolved in 100 ml of boiling acetone. 25 ml of diluted hydrochloric acid were added, the solution boiled for 5 minutes and then allowed to cool. Upon crystallization, 0.85 g of androstan-17β-ol-3-one was obtained, melting point 175°C to 178°C.
Therapeutic Function
Androgen
Allgemeine Beschreibung
Dihydrotestosterone (Item No. 15874) is an analytical reference standard categorized as an anabolic androgenic steroid. Anabolic steroids, including dihydrotestosterone, have been used to enhance physical performance in athletes. Dihydrotestosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
Nebenwirkungen
In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light-colored stools, dark-colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.
Serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); swelling of the arms or legs (especially ankles); frequent or persistent erections, or breast tenderness or enlargement (male patients); or voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients).
Common stanozolol side effects may include: new or worsening acne; difficulty sleeping; headache; or changes in sexual desire.
Einzelnachweise
https://en.wikipedia.org/wiki/Dihydrotestosterone#Medical_use
Swerdloff, R. S., and C. Wang. "Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent."Baillieres Clin Endocrinol Metab 12.3(1998):501.

Stanolone Upstream-Materialien And Downstream Produkte

Androstanolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

521-18-6, Stanolone Verwandte Suche:

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