Domiphenbromid

Bezeichnung:Domiphenbromid

CAS-Nr538-71-6

Englisch Name:Domiphen bromide

CBNumberCB4271226

SummenformelC22H40BrNO

Molgewicht414.46

MOL-Datei538-71-6.mol

Synonyma

Domiphenbromid

Domiphenbromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	117-119 °C (lit.)
Dichte	1.1411 (rough estimate)
Brechungsindex	1.5570 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene.
Sensitive	Hygroscopic
Merck	14,3415
BRN	3922742
InChIKey	OJIYIVCMRYCWSE-UHFFFAOYSA-M
CAS Datenbank	538-71-6(CAS DataBase Reference)
EPA chemische Informationen	1-Dodecanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-, bromide (1:1) (538-71-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	BQ2030000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
Giftige Stoffe Daten	538-71-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Domiphen bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity. It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination. It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC₅₀ = 1.5 μM in a whole-cell patch-clamp assay). Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.
Originator
Bradosol,Ciba,US,1958
Verwenden
Domiphen bromide is employed as a phase transfer catalyst in synthetic chemistry. It is used as a quaternary ammonium cation with cationic surfactant properties. Further, it is used as an antiseptic and an active pharmaceutical ingredient.
Verwenden
Antiinfective, topical.
Definition
ChEBI: Domiphen bromide is an aromatic ether.
Manufacturing Process
7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization from acetone, melts at 112°C. It is a white crystalline powder which dissolves easily in water to give a neutral reaction.
Therapeutic Function
Topical antiinfective
Sicherheitsprofil
Poison by intraperitoneal and intravenous routes. hfutauon data reported. When heated to decomposiuon it emits very toxic fumes of NOx, NH3, and Br-. See also BROMIDES.

Domiphen bromide Upstream-Materialien And Downstream Produkte

Domiphenbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

538-71-6, Domiphen bromide Verwandte Suche:

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