Pipemidinsure Produkt Beschreibung

Pipemidic acid Struktur
51940-44-4
  • CAS-Nr.51940-44-4
  • Bezeichnung:Pipemidinsure
  • Englisch Name:Pipemidic acid
  • Synonyma:Pipemidinsure
    palin;1489rb;pipram;rb1489;dolcol;pipemid;PB-1489;xylique;pipedac;deblaston
  • CBNumber:CB3748118
  • Summenformel:C14H17N5O3
  • Molgewicht:303.32
  • MOL-Datei:51940-44-4.mol
Pipemidinsure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :251-255℃
  • Siedepunkt: :717℃
  • Dichte :1.1931 (rough estimate)
  • Brechungsindex :1.7000 (estimate)
  • Flammpunkt: :>110°(230°F)
  • Löslichkeit :1 M NaOH: soluble50mg/mL
  • Wasserlöslichkeit :Soluble in 1N sodium hydroxide or in DMSO. Insoluble in water
  • Sensitive  :Light Sensitive
  • CAS Datenbank :51940-44-4(CAS DataBase Reference)
Sicherheit
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :42/43
  • S-Sätze: :22-36/37-45
  • WGK Germany  :2
  • RTECS-Nr. :UV1153800
  • HS Code  :29335990
  • Toxizität :LD50 in mice (mg/kg): 4000 orally; 1000 i.p., 50 i.v. (Ficicchia)

Pipemidic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Verwenden antibacterial
  • Definition ChEBI: A pyridopyrimidine that is 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid substituted at position 2 by a piperazin-1-yl group and at position 8 by an ethyl group. Used for treatment of gastrointestinal, biliary, and urinary infecti ns.
  • Pharmazeutische Anwendungen An orally administered pyridopyrimidine derivative with a 7-piperazinyl moiety. The piperazinyl moiety at C-7 increases in-vitro activity against Ps. aeruginosa. Pipemidic acid is inactive against Gram-positive bacteria or anaerobes
    It is well absorbed orally. The drug is rapidly metabolized, primarily to acetyl, formyl and oxo derivatives, which exhibit much reduced antibacterial activity. It is eliminated in the urine, 50–85% of a dose appearing over the first 24 h, less than 2% as inactive metabolites. Non-renal clearance accounts for 10–40% of a dose in the young, rising to 40–70% in elderly subjects, thereby compensating for possible renal insufficiency. No dosage adjustment is necessary in patients with mild renal insufficiency. Some of the drug is eliminated in the bile and a significant portion appears in the feces.
    Nausea and vomiting are common; dizziness, weakness and grand mal seizures have been observed, principally in the elderly. A number of reactions have been sufficiently severe to require discontinuation of therapy. Clinical use is restricted to urinary tract infections.
Pipemidic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pipemidinsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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51940-44-4, Pipemidic acid Verwandte Suche:
  • Pipemidic Acid Anhydrous
  • 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido-(2,3-d)primidine-6-carboxylic acid
  • Deblaston(Madaus,Kolu)
  • pipemidic acid, PPA
  • 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylicacidtrihydrate
  • PB-1489
  • Pipemidic acid,8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid
  • Pyrido[2,3-d]pyriMidine-6-carboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-
  • Pipemidic acid Solution, 1000ppm
  • 8-ETHYL-5,8-DIHYDRO-5-OXO-2-[1-PIPERAZINYL]PYRIDO[2,3-D]-PYRIMIDINE-6-CARBOXYLIC ACID
  • LABOTEST-BB LT00772244
  • PIPEMIDIC ACID
  • 1489rb
  • pipemid
  • piperamicacid
  • pipram
  • pyrido(2,3-d)pyrimidine-6-carboxylicacid,5,8-dihydro-8-ethyl-5-oxo-2-(1-piper
  • rb1489
  • xylique
  • 5,8-dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxy
  • acideethyl-8oxo-5piperazinyl-2dihydro-5,8pyrido(2,3-d)pyrimidine-6carbo
  • acidopipemidico
  • deblaston
  • dolcol
  • palin
  • pipedac
  • 51940-44-4
  • Antibiotics N-S
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • PIPEDAC
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