Tamsulosin

Bezeichnung:Tamsulosin

CAS-Nr106133-20-4

Englisch Name:Tamsulosin

CBNumberCB3128875

SummenformelC20H28N2O5S

Molgewicht408.51

MOL-Datei106133-20-4.mol

Tamsulosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	226-228°C
Siedepunkt	595.5±60.0 °C(Predicted)
Dichte	1.191±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO: 100 mg/mL (244.79 mM)
Aggregatzustand	Solid
pka	10.08±0.60(Predicted)
Farbe	White to off-white
CAS Datenbank	106133-20-4(CAS DataBase Reference)

Sicherheit

Giftige Stoffe Daten

106133-20-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Tamsulosin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Tamsulosin hydrochloride is the first in the class of potent and selective α- 1A adrenoceptor antagonists introduced for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). In a clinical study, significant improvement in irritative and obstructive symptoms has been reported for tamsulosin treated patients with BPH. ln vitro studies in human penile erectile tissue and vas deferens indicated that tamsulosin may be of use in treating male sexual dysfunction.
Originator
Yamanouchi (Japan)
Verwenden
chemotherapy drug
Verwenden
tamsulosin
Definition
ChEBI: Tamsulosin is a 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It is a conjugate base of a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin.
Manufacturing Process
In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.
Trademarks
Harnal
Therapeutic Function
Antihypertensive
Allgemeine Beschreibung
Tamsulosin (Flomax), a nonquinazoline benzensulfonamide,is the first in the class of subtype selective 1Ablocker.It is many folds more selective for α1A-receptorsthan for the other α1-receptors. This selectivity may favorblockade of α1A-receptors found in the prostate gland overthose found in vascular tissue. Tamsulosin is efficacious inthe treatment of BPH with little effect on blood pressure.Orthostatic hypotension is not as great with this agent aswith the nonselective quinazolines.

Tamsulosin Upstream-Materialien And Downstream Produkte

Tamsulosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

106133-20-4, Tamsulosin Verwandte Suche:

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