Molsidomin

Bezeichnung:Molsidomin

CAS-Nr25717-80-0

Englisch Name:Molsidomine

CBNumberCB2234645

SummenformelC9H14N4O4

Molgewicht242.23

MOL-Datei25717-80-0.mol

Synonyma

Molsidomin

Molsidomin physikalisch-chemischer Eigenschaften

Schmelzpunkt	140-141°C
Siedepunkt	385.05°C (rough estimate)
Dichte	1.3186 (rough estimate)
Brechungsindex	1.6300 (estimate)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.
pka	pK (100°) 3.0 ± 0.1
Farbe	White to Off-White
maximale Wellenlänge (λmax)	317nm(MeOH)(lit.)
Merck	14,6234
CAS Datenbank	25717-80-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	WU7677400
HS Code	29349990
Toxizität	LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)

Gefahreninformationscode (GHS)

Molsidomine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to Off-White Solid
Originator
Corvasal,Hoechst
Verwenden
Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitr ic oxide donor.
Verwenden
Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.
Definition
ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines.
Manufacturing Process
1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.
Trademarks
Corvaton (Hoechst-Roussel).
Therapeutic Function
Coronary vasodilator

Molsidomine Upstream-Materialien And Downstream Produkte

Molsidomin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

25717-80-0, Molsidomine Verwandte Suche:

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