3-Morpholinosydnonimine hydrochloride Struktur

3-Morpholinosydnonimine hydrochloride

Bezeichnung:3-Morpholinosydnonimine hydrochloride

CAS-Nr16142-27-1

Englisch Name:3-Morpholinosydnonimine hydrochloride

CBNumberCB5370997

SummenformelC6H11ClN4O2

Molgewicht206.63

MOL-Datei16142-27-1.mol

3-Morpholinosydnonimine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	186 °C
Dichte	1.303 at 20℃
storage temp.	-20°C
Löslichkeit	Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
Aggregatzustand	White solid
Farbe	White
Wasserlöslichkeit	soluble
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
LogP	-6.28 at 25℃
CAS Datenbank	16142-27-1(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	WU7687800
HS Code	29349990

Gefahreninformationscode (GHS)

3-Morpholinosydnonimine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
3-Morpholinosydnonimine hydrochloride has been used:
- as a peroxynitrite donor standard to study the accumulation of peroxynitrite?in?Arabidopsis thaliana
- to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
- as a ROS to study its effects on mouse embryonic fibroblasts
Verwenden
SIN-1 is a metabolite of the vasodilator molsidomine and is considered to be a peroxynitrite releasing compound
Verwenden
3-Morpholinosydnonimine hydrochloride is a metabolite of the vasodilator Molsidomine (M488002) and is considered to be a peroxynitrite releasing compound. Molsidomine Impurity A.
Indications
Linsidomine (SIN-1) is an active metabolite of the antianginal drug molsidomine. Its mechanism of action upon the corpus cavernosum involves the release of nitric oxide. Injected intracavernosally it can produce penile erections, but its clinical usefulness has not been fully established.
Biologische Aktivität
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
Biochem/physiol Actions
3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.
Lager
Store at +4°C
Einzelnachweise
1) Nishikawa?et al.?(1982)?Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites;?J. Pharmacol. Exp. Ther.?220?183 2) Hogg?et al.?(1992)?Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J.?281?419 3) Kirsch?et al.?(1998)?Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem.?273?12716 4) Priora?et al.?(2011)?In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res.?64?289 5) Ren?et al.?(2017)?Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor;?ACS Omega.?2?243

3-Morpholinosydnonimine hydrochloride Upstream-Materialien And Downstream Produkte

3-Morpholinosydnonimine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

16142-27-1, 3-Morpholinosydnonimine hydrochloride Verwandte Suche:

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