Cilnidipine

Bezeichnung:Cilnidipine

CAS-Nr132203-70-4

Englisch Name:Cilnidipine

CBNumberCB2193117

SummenformelC27H28N2O7

Molgewicht492.52

MOL-Datei132203-70-4.mol

Cilnidipine physikalisch-chemischer Eigenschaften

Schmelzpunkt	97-99°C
Siedepunkt	652.6±55.0 °C(Predicted)
Dichte	1.240±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	H2O: ≤2mg/mL
pka	2.61±0.70(Predicted)
Aggregatzustand	powder
Farbe	light yellow
Merck	14,2275
InChIKey	KJEBULYHNRNJTE-DHZHZOJOSA-N
CAS Datenbank	132203-70-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	41
S-Sätze:	26-39
WGK Germany	3
RTECS-Nr.	US7975550
HS Code	29333990
Toxizität	LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)

Gefahreninformationscode (GHS)

Cilnidipine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.
Beschreibung
Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg. Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.
Chemische Eigenschaften
Yellow Crystalline Solid
Originator
Fujirebio (Japan)
Verwenden
Cilnidipine has been used:
- in cell viability assay of pheochromocytoma (nPC12) cells
- in photoirradiation and photodegradation studies
- to understand effect on albuminuria in diabetic nephropathy
Verwenden
A dihydropyridine calcium channel blocker.
Verwenden
antihypertensive;dihydropyridine calcium channel blocker
Definition
ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Trademarks
Cinalong;Siscard;Atelec
Biologische Aktivität
Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.
Lager
+4°C

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