Orciprenalin

Orciprenaline Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Alupent, Boehringer Ingelheim ,W. Germany ,1961

• Verwenden

  Bronchodilator.

• Definition

  ChEBI: Metaproterenol is a member of phenylethanolamines.

• Manufacturing Process

  In an initial operation, 3,5-diacetoxyacetophenone was reacted first with bromine and then with isopropylamine to give 1-(3,5-dihydroxyphenyl)-2- isopropylaminoethanone.
  59 g of 1-(3,5-dihydroxy-phenyl)-2-isopropylaminoethanone (free base) were dissolved in 590 cc of methanol, and the solution was hydrogenated in the presence of about 80 g Raney nickel at room temperature and under a pressure of 5 atm. Hydrogen absorption was terminated after a few minutes. The catalyst was separated by vacuum filtration, and the filtrate, an ethanolic solution of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane, was admixed with the calculated amount of an alcoholic 20% sulfuric acid solution. A crystalline precipitate formed which was filtered off and washed with alcohol. For purification, the product was dissolved in water and the solution was filtered through iron-free charcoal.
  Thereafter, the filtrate was evaporated to dryness in vacuo and the residue was taken up in alcohol. The crystalline precipitate which separated out after some standing was separated by vacuum filtration and washed with alcohol. After recrystallization from 90% alcohol, 61 g (83.2% of theory) of 1-(3,5- dihydroxyphenyl)-1-hydroxy-2-isopropylamino-ethane sulfate, MP 202° to 203°C, was obtained.

• Therapeutic Function

  Bronchodilator

• Clinical Use

  Metaproterenol was the first β- sympathomimetic drug with metabolic stability to achieve wide clinical use.

Orciprenaline Upstream-Materialien And Downstream Produkte

Orciprenalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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