Sulisobenzon

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H412：Schädlich für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

• Beschreibung

  UV light absorber 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (INCI title Benzophenone-4; Hereinafter to be referred to as BP-4) can absorb UV-A and UV-B simultaneously; Be a kind of wide spectrum, water-soluble UV light absorber; To advantages such as light, Heat stability is goods, be used for water-soluble makeup and make sun-screening agent. Being the cosmetics additive that Europe and Japanese rules allow use, it is also the first kind of sun-screening agent of drugs approved by the FDA and is simultaneously the UV light absorber that China's cosmetics health standard (2002 editions) permission. Its acute toxicity: the oral medium lethal dose LD50=3530mg/kg of mouse belongs to the low toxicity chemical.

• Chemische Eigenschaften

  white to yellowish powder

• Originator

  Uval,Dome,US,1965

• Verwenden

  Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.

• Verwenden

  2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. Sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.

• Definition

  ChEBI: Sulisobenzone is a member of benzophenones.

• Manufacturing Process

  663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.

• Trademarks

  Sungard (Bayer).

• Therapeutic Function

  Sunscreen agent

• Allgemeine Beschreibung

  Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.

• Flammability and Explosibility

  Non flammable

• Kontakt-Allergie

  BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.

• Synthese

  Adding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of materials in the kettle to be 20 to 25 DEG C through jacket water bath cooling by controlling the dripping speed of the chlorosulfonic acid, and reacting for 20 to 25 hours; performing centrifugal filtering separation on a product after the reaction is finished, washing the product by using the corresponding solvent, and drying the product under the protection of the nitrogen; and recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packed tower in a water circulation mode to form a 20 to 30 % hydrochloric acid aqueous solution, and recycling the 2-hydroxy-4-methoxybenzophenone and the 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.

• Verordnung (Regulations)

  2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a cosmetic material; the allowance state of countries in the world (maximum usage quantity wt%) is as follows: Europe: 5.0%; Australia: 10%; Japan: 10.0%; The U.S.: 10.0%; China: 5%.

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Upstream-Materialien And Downstream Produkte

Sulisobenzon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(531)Suppliers

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