Propoxur (ISO)

Bezeichnung:Propoxur (ISO)

CAS-Nr114-26-1

Englisch Name:Propoxur

CBNumberCB1348734

SummenformelC11H15NO3

Molgewicht209.24

MOL-Datei114-26-1.mol

Synonyma

Propoxur (ISO)

2-Isopropoxyphenylmethylcarbamat

2-(1-Methylethoxy)phenylmethylcarbamat

Propoxur (ISO) physikalisch-chemischer Eigenschaften

Schmelzpunkt	91°C
Siedepunkt	348.6°C (rough estimate)
Dichte	1.1200
Dampfdruck	1.3 x 10^-3 Pa (20 °C)
Brechungsindex	1.5080 (estimate)
Flammpunkt	-18 °C
storage temp.	2-8°C
Löslichkeit	Chloroform: slightly; Methanol: slightly
pka	12.28±0.46(Predicted)
Aggregatzustand	Minute Crystals
Farbe	White to off-white
Wasserlöslichkeit	Slightly soluble. 0.2 g/100 mL
Merck	13,7929
BRN	1879891
Expositionsgrenzwerte	OSHA TWA: 0.5 mg/m3; ACGIH TLV: TWA 0.5 mg/m3.
CAS Datenbank	114-26-1
NIST chemische Informationen	2-Isopropoxyphenyl N-methylcarbamate(114-26-1)
EPA chemische Informationen	Propoxur (114-26-1)

Sicherheit

Kennzeichnung gefährlicher	T;N,N,T,Xn,F
R-Sätze:	25-50/53-67-65-38-11
S-Sätze:	37-45-60-61-62
RIDADR	UN 2811/2588
OEB	C
OEL	TWA: 0.5 mg/m3
WGK Germany	3
RTECS-Nr.	FC3150000
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	114-26-1(Hazardous Substances Data)
Toxizität	LD50 orally in male, female rats: 83, 86 mg/kg (Gaines)

Gefahreninformationscode (GHS)

Propoxur Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSES, KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Methylisocyanat und Stickstoffoxiden.
ARBEITSPLATZGRENZWERTE
TLV: 0.5 mg/m?(als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); BEI vorhanden; (ACGIH 2005).
MAK: (Einatembare Fraktion) 2 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(8); (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Möglich sind Auswirkungen auf Nervensystem, Leber und Nieren mit nachfolgendem Atemversagen, Krämpfen und Gewebeschäden. Cholinesterasehemmer. Exposition kann zum Tod führen.
LECKAGE
NICHT in die Kanalisation spülen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R38:Reizt die Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S37:Geeignete Schutzhandschuhe tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.
Beschreibung
Propoxur, 2-isopropoxyphenyl methylcarbamate (IUPAC),forms colorless crystals, which are moderately soluble in most organic solvents.
Beschreibung
Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase. It is lethal to German cockroaches (B. germanica) with LD₅₀ values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC₅₀s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis. It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.
Chemische Eigenschaften
White, crystalline powder; odorless. Soluble in most alcohols; very slightly solublein water; unstable in highly alkaline media; stableunder normal conditions.
Chemische Eigenschaften
Propoxur is a white to tan crystalline solid or powder. Faint characteristic odor
Verwenden
Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by r eversibly inactivating the enzyme acetylcholinesterase in insects.
Verwenden
Insecticide used for control of chewing and sucking insects in fruits, vegetables, ornamentals and forestry.
Verwenden
Propoxur is an insecticide with contact and stomach action. It is mainly used in food storage areas. It also controls chewing and sucking pests on a wide range of crops.
synthetische
Propoxur is prepared by reaction of 2-isopropoxyphenol with methylisocyanate.
Definition
ChEBI: A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.
Allgemeine Beschreibung
White to tan crystalline powder with a faint, characteristic odor. Used as an insecticide.
Reaktivität anzeigen
Propoxur is incompatible with the following: Strong oxidizers, alkalis [Note: Emits highly toxic methyl isocyanate fumes when heated to decomposition.] .
Hazard
Toxic by ingestion and inhalation. Cholinesterase inhibitor. Possible carcinogen.
Health Hazard
A highly toxic substance by ingestion, andpossibly by most other routes of exposure;moderately toxic by inhalation and skin contact; cholinesterase inhibitor; toxic effects aresimilar to those of other carbamate pesticidesand include excessive salivation, lacrimation, slow heart rate, blurred vision, twitchingof muscle and lack of coordination, nausea,weakness, diarrhea and abdominal pain; oralintake of probably 1.5–3 g could be fatal toadult humans; a teratogenic substance, producing adverse reproductive effects in experimental animals.
LD50 oral (rat): 70 mg/kg
LD50 skin (rat): 800 mg/kg
LC50 inhalation (rat): 1440 mg/m³/1 hr.
Landwirtschaftliche Anwendung
Insecticide, Molluscicide: Not approved for use in EU countries. A non-systemic insecticide compatible with most fungicides and insecticides except those that are alkaline. It is often used in combination with azinphosmethyl, chlorpyrifos, cyfluthrin, dichlorvos, disulfoton or methocarb. It is used on sugar cane, cocoa, pome and stone fruit, grapes, maize, hops, rice, sugar beets, vegetables, cotton, and forestry and ornamentals to control pests such as chewing and sucking insects, ants, crickets, flies, mosquitoes, millepedes, jassids and cockroaches.
Handelsname
(There are currently 695 registered active and/or canceled and/or transferred products in the U.S.) ARPROCARB®; BAY®; BAY® 5122; BAYER®; BAYER® B 5122; BAYGON®; BIFEX®; BLATTANEX®; BLATTOSEP®; BOLFO®; BO Q 5812-315®; BORUHO®; BORUHO® 50; BRIFUR®; BRYGOU®; CHEMAGRO® 9010; COMPOUND 39007; DALF DUST®; INVISI-GARD®; PILLARGON®; PRENTOX CARBAMATE®; PROPOGON®; PROPOTOX®; PROPOXYLOR®; PROPYON®; RHODEN®; SENDRAN®; SUNCIDE®; TENDEX®; TUGEN®; UNDEN®; UNDENE®
mögliche Exposition
Personnel engaged in the manufacture, formulation and application of this organonitrogen agricul- tural chemical and pesticide.
Environmental Fate
Groundwater. According to the U.S. EPA (1986) propoxur has a high potential to leach to groundwater.
Photolytic. Though no products were identified, the half-life in UV irradiated water (λ >290 nm) was 87.9 hours (Jensen-Korte et al., 1987). When propoxur in ethanol was irradiated by UV light, only one unidentified cholinesterase inhibitor formed. Exposure to sunlight for 3 hours yielded no photodecomposition products (Crosby et al., 1965).
Chemical/Physical. Decomposes at elevated temperatures forming methyl isocyanate (Windholz et al., 1983) and nitrogen oxides (Lewis, 1990). Hydrolyzes in water to 1- naphthol and 2-isopropoxyphenol (Miles et al., 1988). At pH 6.9, half-lives of 78 and 124 days were reported under aerobic and anaerobic conditions, respectively (Kanazawa, 1987). Miles et al. (1988) studied the rate of hydrolysis of propoxur in phosphate-buffered water (0.01 M) at 26°C with and without a chlorinating agent (10 mg/L hypochlorite solution). The hydrolysis half-lives at pH 7 and 8 with and without chlorine were 3.5 and 10.3 days and 0.05 and 1.2 days, respectively (Miles et al., 1988). The reported hydrolysis half-lives of propoxur in water at pH 8, 9 and 10 were 16.0 days, 1.6 days and 4.2 hours, respectively (Aly and El-Dib, 1971). In a 0.50 N sodium hydroxide solution at 20°C, the hydrolysis half-life was reported to be 3.0 days (El-Dib and Aly, 1976).
Stoffwechselwegen
The principal pathways of propoxur metabolism in plants and animals are deisopropylation, hydrolysis of the carbamate ester to form a phenol and conjugation. Minor metabolites are formed by hydroxylation of the N-methyl group and the phenyl ring. Only insects form metabolites hydroxylated at the isopropoxy group.
Versand/Shipping
UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Degradation
Propoxur is hydrolysed by strong alkalis. DT₅₀ values at pH 7 and 9 (22°C) were 93 days and 30 hours (PM). Propoxur was hydrolysed in neutral aerated river water (half-life <2 days at 25 °C) (Kuhr and Dorough, 1976).
It is not rapidly photodegraded in aqueous solutions (PM) and is more stable than carbaryl (Crosby et al., 1965). Solutions of unlabelled propoxur in isopropanol, cyclohexane or cyclohexene were irradiated for 48 hours with a high-pressure Hg lamp with light of wavelength less than 280 nm filtered out. Analysis of samples was by HPLC. Photodecomposition was faster in isopropanol than in the hydrocarbon solvents. The main pathway of photodecomposition (see Scheme 1) was β-cleavage of the carbamate ester group to form isopropyl phenyl ether (2). 2-Isopropoxyphenol (3) was detected as a trace product (Schwack and Kopf, 1992).
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alkalis, heat, and mois- ture. Emits highly toxic methyl isocyanate fumes when heated to decomposition.
Waste disposal
In accordance with 40CFR165, follow recommendations for the disposal of pes- ticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contact- ing your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern- ing storage, transportation, treatment, and waste disposal.

Propoxur Upstream-Materialien And Downstream Produkte

Propoxur (ISO) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

114-26-1, Propoxur Verwandte Suche:

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