1,2-Dihydroxybenzol

Bezeichnung:1,2-Dihydroxybenzol

CAS-Nr120-80-9

Englisch Name:Catechol

CBNumberCB7300091

SummenformelC6H6O2

Molgewicht110.11

MOL-Datei120-80-9.mol

Synonyma

Brenzcatechin

1,2-Dihydroxybenzol

Pyrocatechol

1,2-Dihydroxybenzol physikalisch-chemischer Eigenschaften

Schmelzpunkt	100-103 °C (lit.)
Siedepunkt	245 °C (lit.)
Dichte	1,371 g/cm³
Dampfdichte	3.8 (vs air)
Dampfdruck	1 mm Hg ( 75 °C)
Brechungsindex	1.6120 (estimate)
Flammpunkt	279 °F
storage temp.	Store below +30°C.
Löslichkeit	430g/l
Aggregatzustand	Crystalline Flakes
pka	9.85(at 20℃)
Farbe	white to faintly beige
PH	6 (100g/l, H2O, 20℃)
Explosionsgrenze	1.97%(V)
Wasserlöslichkeit	430 g/L (20 ºC)
Sensitive	Air & Light Sensitive
Merck	14,7999
BRN	471401
Expositionsgrenzwerte	TLV-TWA 5 ppm (～22 mg/m³) (ACGIH). .
Stabilität	Stable. Substances to be avoided include acid chlorides, acid anhydrides, bases, oxidizing agents, nitric acid. Light sensitive; may discolour on exposure to air. Combustible.
LogP	0.93
CAS Datenbank	120-80-9(CAS DataBase Reference)
NIST chemische Informationen	1,2-Benzenediol(120-80-9)
IARC	2B (Vol. 15, Sup 7, 71) 1999
EPA chemische Informationen	Catechol (120-80-9)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	21/22-36/38-68-43
S-Sätze:	22-26-37-39
RIDADR	UN 2811 6.1/PG 3
OEB	A
OEL	TWA: 5 ppm (20 mg/m3) [skin]
WGK Germany	2
RTECS-Nr.	UX1050000
TSCA	Yes
HS Code	2907 29 00
HazardClass	6.1
PackingGroup	III
Giftige Stoffe Daten	120-80-9(Hazardous Substances Data)
Toxizität	LD50 in mice (mg/kg): 260 orally; 190 i.p. (Lehman)

Gefahreninformationscode (GHS)

Catechol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH. VERFäRBEN SICH BRAUN BEI KONTAKT MIT LUFT UND LICHT.
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung reizender Rauche. Reagiert mit Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV: 5 ppm (als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Haut, die Atemwege und den Verdauungstrakt. Die Substanz verätzt die Augen. Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgender Depression, Krämpfen und Atemversagen. Exposition kann zu Blutdrucksteigerung führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37:Geeignete Schutzhandschuhe tragen.
Beschreibung
Catechol is a white crystalline solid. Turnsbrown on contact with light and air. Molecularweight=110.12; Specific gravity (H2O:1)=1.3; Boilingpoint=245.5℃; Freezing/Melting point=104℃. It sublimes readily; Vapor pressure=10 mmHg at 117℃; Flashpoint=127℃; Autoignition temperature=512℃.Explosive Limits in air: LEL=1.4%; UEL-Unknown.Hazard Identification (based on NFPA 704 M RatingSystem): Health 3, Flammability 1, Reactivity 2. Solubilityin water=44%.
Chemische Eigenschaften
Catechol also called Pyrocatechol is a white crystalline solid. Turns brown on contact with light and air.
Chemische Eigenschaften
Off-white powder
Verwenden
In the manufacture of rubber antioxidants and monomer inhibitors to stop radical polymerization; in dyes, as a photographic developer; in formulations for pharmaceuticals, perfumes, inks, and insecticides
Verwenden
In photography; dyeing fur; as reagent.
Verwenden
Catechol is used in photography, in dyeing fur, and as a topical antiseptic.
Vorbereitung Methode
Catechol may be obtained by the fusion of o-phenolsulfonic acid with alkali, by heating chorophenol with a solution of sodium hydroxide at 200°C in an autoclave, or by cleavage of the methyl ether group of guaiacol (obtained from beechwood tar) with hydriodic acid.
Definition
A colourless crystalline PHENOL containing two hydroxyl groups. It is used in photographic developing.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 4275, 1980 DOI: 10.1021/jo01310a003
Allgemeine Beschreibung
Solid; white; odorless. Sinks and mixes with water.
Air & Water Reaktionen
Turns brown on exposure to air and light, especially when moist. Water soluble. Aqueous solutions soon turn brown on exposure to air and light.
Reaktivität anzeigen
POISONOUS GASES MAY BE PRODUCED WHEN HEATED. Pyrocatechol may form toxic fumes at high temperatures. [USCG, 1999]. Pyrocatechol can react with acid chlorides, acid anhydrides, bases and oxidizing agents. Pyrocatechol reacts violently on contact with concentrated nitric acid. Pyrocatechol acts as a reducing agent .
Hazard
Strong irritant. Toxic by skin absorption. Eye and upper respiratory tract irritant, and der- matitis. Possible carcinogen.
Health Hazard
Acute oral and percutaneous toxicity of pyrocatechol is greater than that of phenol; inhalation toxicity is less than that of phenol. The toxic symptoms include weakness, muscular pain, dark urine, tremor, dyspnea, and convulsions. Large amounts can produce degenerative changes in renal tubules. Large doses can cause death due to respiratory failure. Skin contact can cause eczematous dermatitis.
LD50 value, oral (rats): 260 mg/kg
LD50 value, skin (rabbits): 800 mg/kg.
Health Hazard
DUST: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. SOLID: Will burn skin and eyes. Harmful if swallowed.
Brandgefahr
Combustible. POISONOUS GASES MAY BE PRODUCED WHEN HEATED. May form toxic fumes at high temperatures.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and parenteral routes. Moderately toxic by skin contact. Experimental reproductive effects. Can cause dermatitis on skin contact. An allergen. Human mutation data reported. Questionable carcinogen. Systemic effects sirmlar to those of phenol. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Hypergolic reaction with concentrated nitric acid. To fight fire, use water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also PHENOL.
mögliche Exposition
Used as a chemical intermediate; pharmaceutical and veterinary drug; as an antiseptic; in photography; in dyestuff manufacture and application. It is also used in electroplating, in the formulation of specialty inks; in antioxidants; and light stabilizers.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Note to physician: Treat for methemoglobinemia.Spectrophotometry may be required for precise determination of levels of methemoglobinemia in urine.
Carcinogenicity
Catechol has been extensively studied for its role in carcinogenesis of the rat glandular stomach; it was concluded that pyrocatechol is carcinogenic. When rats and mice were administered 0.8% pyrocatechol in their feed for life, there was an increase in glandular stomach adenocarcinoma in both male and female rats. Pyrocatechol also caused hyperplasia of the glandular stomach in both rats and mice, a mechanism that could cause promotion of carcinogen-initiated cells; no effects on the esophagus or urinary bladder were reported. There were no cutaneous neoplasms when pyrocatechol was applied in dermal studies. Catechol may be classified as a cocarcinogen because it enhanced the number and/or incidence of lesions in the stomach induced by several carcinogenic nitrosamines and cutaneous neoplasms when administered dermally together with several carcinogens.
Lager
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with catecholyou should be trained on its proper handling and storage.Before entering confined space where this chemical may bepresent, check to make sure that an explosive concentrationdoes not exist. Store in tightly closed containers in a cool,well-ventilated area away from strong oxidizers and acids.Use only nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.
Versand/Shipping
UN 2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
läuterung methode
Crystallise catechol from *benzene or toluene and sublime it in vacuo. [Rozo et al. Anal Chem 58 2988 1986, Beilstein 6 IV 5557.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Catechol Upstream-Materialien And Downstream Produkte

1,2-Dihydroxybenzol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

120-80-9, Catechol Verwandte Suche:

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