4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, Mononatriumsalz, [2S-[2α,5α,6β,(S*)]]-

Bezeichnung:4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, Mononatriumsalz, [2S-[2α,5α,6β,(S*)]]-

CAS-Nr59703-84-3

Englisch Name:Piperacillin sodium salt

CBNumberCB1237614

SummenformelC23H26N5NaO7S

Molgewicht539.54

MOL-Datei59703-84-3.mol

Synonyma

4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, Mononatriumsalz, [2S-[2α,5α,6β,(S*)]]-

4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, Mononatriumsalz, [2S-[2α,5α,6β,(S*)]]- physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-185 C (dec.)
Siedepunkt	793℃
Brechungsindex	180 ° (C=0.8, H2O)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless to faintly yellow
Farbe	White to Almost white
Wasserlöslichkeit	Soluble in ethanol, water and methanol.
Merck	14,7463
BRN	5373920
Stabilität	Hygroscopic
InChIKey	WCMIIGXFCMNQDS-IDYPWDAWSA-M
CAS Datenbank	59703-84-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	42/43
S-Sätze:	22-36/37-45
WGK Germany	2
RTECS-Nr.	XI0180000
HS Code	29411099
Toxizität	LD50 in mice, rats, dogs, monkeys (g/kg): 5, 2.7, >6, >4 i.v. (Takai)

Gefahreninformationscode (GHS)

Piperacillin sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Piperacillin was synthesized by Toyama Chemicals Company in 1976by acylation of the amino residue of ampicillin. It shows excellent activity against a wide range of grampositive and gram-negative bacteria and has been used as the most potent semisynthetic penicillin. Piperacillin is administered intravenously or intramuscularly for therapy of sepsis, meningitis, respiratory and urinary tract infections, and for abdominal infections caused by Staphylococcus, Streptococcus, Escherichia coli, Klebsiella, Haemophilus influenzae, Serratia marcescens, Pseudomonas aeruginosa, Proteus, Enterobacter, Citrobacter, and Bacteroides.
Chemische Eigenschaften
White to off-white crystalline powder
Verwenden
A broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria. Piperacillin sodium salt is an antibiotic. It is used in pharmacokinetic studies to optimize antimicrobial therapy and in hypersensitivity reactions. It is involved in the study of multidrug-resistant organisms. It acts as an antibiotic related to penicillin.
Verwenden
Penicillin antibacterial.
Definition
ChEBI: Piperacillin sodium is an organic sodium salt. It contains a piperacillin(1-).
Trademarks
Pipracil (Wyeth).

4-Thia-1-azabicyclo[3.2.0]heptan-2-carbonsure, 6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-, Mononatriumsalz, [2S-[2α,5α,6β,(S*)]]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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