Amobarbital

Bezeichnung:Amobarbital

CAS-Nr57-43-2

Englisch Name:Amobarbital

CBNumberCB0741976

SummenformelC11H18N2O3

Molgewicht226.27

MOL-Datei57-43-2.mol

Synonyma

Amobarbital

Amobarbital physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-158°C
Siedepunkt	367.89°C (rough estimate)
Dichte	1.1376 (rough estimate)
Brechungsindex	1.4620 (estimate)
Flammpunkt	9℃
storage temp.	-20°C
pka	8.0(at 25℃)
Farbe	bitter crystals or leaflets from water
Wasserlöslichkeit	<0.1 g/100 mL at 18.5 ºC
Stabilität	Stable. Incompatible with strong oxidizing agents. Hygroscopic.
CAS Datenbank	57-43-2(CAS DataBase Reference)
NIST chemische Informationen	Barbituric acid, 5-ethyl-5-isoamyl-(57-43-2)
EPA chemische Informationen	Amobarbital (57-43-2)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	16-36/37-45
RIDADR	3249
WGK Germany	1
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933530000
Giftige Stoffe Daten	57-43-2(Hazardous Substances Data)
Toxizität	LD50 in mice (mg/kg): 212 s.c. (Irrgang)
DEA Controlled Substances	CSCN: 2126 CSA SCH: Schedule III NARC: No

Gefahreninformationscode (GHS)

Amobarbital Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Crystalline Solid
Originator
Hypnotal,Pharmacal
Verwenden
Controlled substance (depressant). Sedative, hypnotic
Verwenden
Amobarbital for binding at complex I to inhibit mitochondrial electron transport. Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.
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Verwenden
Sedative, hypnotic. Controlled substance (depressant).
Definition
ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hy notic properties.
Manufacturing Process
By interaction of malonic acid diethyl ester with sodium ethylate (molar ratio 1:1) and then with ethyl bromide (molar ratio 1:1) was prepared ethylmalonic acid diethyl ester. From ethylmalonic acid diethyl ester and sodium ethylate (molar ratio 1:1) and then with isopentylbromide was synthesized α-ethyl-α- isopentylmalonic acid diethyl ester. By condensation of α-ethyl-α- isopentylmalonic acid diethyl ester with urea in the presence of sodium ethylate was obtained ethyl-isopentylbarbituric acid.
Trademarks
Amytal Sodium (Lilly); Talamo (Marion Merrell Dow);Altinal;Alupent-sed;Ambese-la;Amobell;Amsal;Amycal;Amydorm;Amylbarb;Amylobeta;Analgilasa;Appenil;Asthmin;Beatol;Bludex;Calavon;Cuaot;Dexaspan;Dexital;Ergo-lonarid;Estimal;Etamyl;Ifenin;Isoamitil sedante;Isobec;Jalonac;Lonarid n;Medi-trol;Mudeka;Mylodorm sustrel;N 8;Neur-amyl;Novambobarb;Novogen;Obe_slim;Placidel;Protasma;Sedo-rythmodan;Sy-dexam;Transital.
Therapeutic Function
Hypnotic, Antiepileptic
Weltgesundheitsorganisation (WHO)
Amobarbital is an intermediate-acting barbiturate which is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO comment for barbiturates. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)
Allgemeine Beschreibung
White crystalline solid with no odor and a slightly bitter taste.
Air & Water Reaktionen
Amobarbital is hygroscopic . Insoluble in water.
Reaktivität anzeigen
Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Hazard
May be a habit forming drug of abuse.
Brandgefahr
Flash point data for Amobarbital are not available, however, Amobarbital is probably combustible.
Sicherheitsprofil
A poison by ingestion,intravenous, intraperitoneal, and subcutaneous routes. Seealso BARBITURATES. When heated to decomposition itemits toxic fumes of NOx.

Amobarbital Upstream-Materialien And Downstream Produkte

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