Hydroxyethyl Cellulose

Bezeichnung:Hydroxyethyl Cellulose

CAS-Nr9004-62-0

Englisch Name:Hydroxyethyl Cellulose

CBNumberCB6356167

SummenformelC29H52O21

Molgewicht0

MOL-DateiMol file

Synonyma

Cellulose-2-hydroxyethylether

2-Hydroxyethylcellulose

Hydroxyethyl Cellulose physikalisch-chemischer Eigenschaften

Schmelzpunkt	288-290 °C (dec.)
Dichte	0.75 g/mL at 25 °C(lit.)
storage temp.	2-8°C
Löslichkeit	H₂O: ≤5 wt. % at 20 °C
Aggregatzustand	powder
Farbe	Light brown powder
Geruch (Odor)	Odorless
PH	pH(20g/l,25℃) : 5.0～8.0
Wasserlöslichkeit	almost transparency
Merck	14,4673
Stabilität	Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides
InChIKey	CWSZBVAUYPTXTG-UHFFFAOYSA-N
SMILES	O1C(CO)C(OC2C(O)C(O)C(OC3C(OCCO)C(O)C(OC)C(CO)O3)C(COC3C(O)C(O)C(OC)C(CO)O3)O2)C(O)C(O)C1C
CAS Datenbank	9004-62-0(CAS DataBase Reference)
EPA chemische Informationen	2-Hydroxyethyl cellulose (9004-62-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25-36/37/38
S-Sätze:	26-36-45-24/25-22
WGK Germany	3
RTECS-Nr.	FJ5958000
F	3
Selbstentzündungstemperatur	725 °F
HS Code	39123980
Giftige Stoffe Daten	9004-62-0(Hazardous Substances Data)
Toxizität	LDLo intravenous in women: 5100mg/kg/6D-

Gefahreninformationscode (GHS)

Hydroxyethyl Cellulose Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSES PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung reizender Rauche.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Reizt möglicherweise mechanisch.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel. Verschüttetes Material in Behältern sammeln.
R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Beschreibung
Hetastarch, another nonproteinaceous colloid, is a complex mixture of ethoxylated amylopectins ranging in molecular weight from 10 to 1,000 kDa (average molecular weight, ~450 kDa). When infused as a 6% solution, hetastarch approximates the activity of human albumin. The larger molecular weights, however, increase its intravascular residence time as well as its plasma expansion effects relative to albumin.
Hetastarch is synthetically produced, so it is degraded more slowly and is less antigenic than other colloids. Despite these advantages, hetastarch is quite expensive and also has no oxygen-carrying capacity.
Chemische Eigenschaften
light yellow powder
Chemische Eigenschaften
Hydroxyethyl cellulose occurs as a white, yellowish-white or grayish-white, odorless and tasteless, hygroscopic powder.
Charakteristisch
Hydroxyethyl cellulose is soluble in hot or cold water, and does not precipitate at high temperature or boiling, so it has a wide range of solubility and viscosity characteristics, as well as non-thermal gelling properties. Hydroxyethyl cellulose is a non-ionic polymer material , can coexist with a wide range of other water-soluble polymers, surfactants, and salts, and is an excellent colloidal thickener for high-concentration dielectric solutions. The water retention capacity of hydroxyethyl cellulose is twice that of methyl cellulose, and it has better flow regulation; the dispersing ability of hydroxyethyl cellulose is comparable to that of methyl cellulose and hydroxypropyl methyl cellulose The specific dispersing ability is the worst, but the protective colloid ability is the strongest.
Verwenden
disintegrant, binder for tabletting
Verwenden
hydroxyethyl cellulose is a thickener, protective colloid, binder, stabilizer, and suspending agent. It is obtained from wood pulp Copyright 2014 Cengage Learning. All Rights Reserved. May not be copied, scanned, or duplicated, in whole or in part. Due to electronic rights, some third party content may be suppressed from the eBook and/or eChapter(s). Editorial Review has deemed that any suppressed content does not materially affect the overall learning experience. Cengage Learning reserves the right to remove additional content at any time if subsequent rights restrictions require it. or chemical cotton by treatment with an alkali.
Verwenden
Thickener, protective colloid, binder, stabilizer and suspending agent.
Definition
A starch derivative containing 90% amylopectin.
Vorbereitung Methode
A purified form of cellulose is reacted with sodium hydroxide to produce a swollen alkali cellulose, which is chemically more reactive than untreated cellulose. The alkali cellulose is then reacted with ethylene oxide to produce a series of hydroxyethyl cellulose ethers.
The manner in which ethylene oxide is added to cellulose can be described by two terms, the degree of substitution (DS) and the molar substitution (MS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethylene oxide. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is 3. MS is defined as the average number of ethylene oxide molecules that have reacted with each anhydroglucose unit. Once a hydroxyethyl group is attached to each unit, it can further react with additional groups in an end-to-end formation. This reaction can continue and there is no theoretical limit for MS.
synthetische
Hydroxyethylcellulose is prepared from alkali cellulose and ethylene oxide. It may be noted that the hydroxyethyl group itself can react with ethylene oxide so that side-chains of varying length may be present in the product. Commercial materials generally contain between 1.4 and 2.0 ethylene oxide residues per glucose residue and have a degree of substitution of about 0.8-1.0.
Trademarks
Hespan (DuPont Merck) .
Allgemeine Beschreibung
Non-ionic water soluble polymer. Aqueous solutions are pseudoplastic. Readily disperses without lumping.
Pharmazeutische Anwendungen
Hydroxyethyl cellulose is a nonionic, water-soluble polymer widely used in pharmaceutical formulations. It is primarily used as a thickening agent in ophthalmic and topical formulations, although it is also used as a binder and film-coating agent for tablets.It is present in lubricant preparations for dry eye, contact lens care, and dry mouth.
The concentration of hydroxyethyl cellulose used in a formulation is dependent upon the solvent and the molecular weight of the grade.
Hydroxyethyl cellulose is also widely used in cosmetics.
Toxikologie
Considered to be non toxic. Use as a food additive indicates good tolerance of small amounts, but excessive amounts or overuse may bring irritant and /or harmful effects. Polysaccharides are not substantially absorbed from the gastrointestinal tract but may produce a laxative effect.
Sicherheit(Safety)
Hydroxyethyl cellulose is primarily used in ophthalmic and topical pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritant material.
Acute and subacute oral toxicity studies in rats have shown no toxic effects attributable to hydroxyethyl cellulose consumption, the hydroxyethyl cellulose being neither absorbed nor hydrolyzed in the rat gastrointestinal tract. However, although used in oral pharmaceutical formulations, hydroxyethyl cellulose has not been approved for direct use in food products.
Glyoxal-treated hydroxyethyl cellulose is not recommended for use in oral pharmaceutical formulations or topical preparations that may be used on mucous membranes. Hydroxyethyl cellulose is also not recommended for use in parenteral products.
Lager
Hydroxyethyl cellulose powder is a stable though hygroscopic material.
Aqueous solutions of hydroxyethyl cellulose are relatively stable at pH 2–12 with the viscosity of solutions being largely unaffected. However, solutions are less stable below pH 5 owing to hydrolysis. At high pH, oxidation may occur.
Increasing the temperature reduces the viscosity of aqueous hydroxyethyl cellulose solutions. However, on cooling, the original viscosity is restored. Solutions may be subjected to freeze–thawing, high-temperature storage, or boiling without precipitation or gelation occurring.
Hydroxyethyl cellulose is subject to enzymatic degradation, with consequent loss in viscosity of its solutions. Enzymes that catalyze this degradation are produced by many bacteria and fungi present in the environment. For prolonged storage, an antimicrobial preservative should therefore be added to aqueous solutions. Aqueous solutions of hydroxyethyl cellulose may also be sterilized by autoclaving.
Hydroxyethyl cellulose powder should be stored in a well-closed container, in a cool, dry place.

Properties and Applications

Index	Results
Appearance	White powder
Viscosity(mPa.s) 2% at 20℃,Brookfield 20rpm sp.5 cps	15,000-25,000
Particle size 80 mesh (180um) %	95.0 min
M.S.(Molar substitution degree) %	2.0-2.5
Moisture ％	≤6.0
Water insoluble %	≤0.5
pH	5.5-7.0
Ash Content %	≤5.0
Bulk density g/L	420-500

Inkompatibilitäten
Hydroxyethyl cellulose is insoluble in most organic solvents. It is incompatible with zein and partially compatible with the following water-soluble compounds: casein; gelatin; methylcellulose; polyvinyl alcohol, and starch.
Hydroxyethyl cellulose can be used with a wide variety of watersoluble antimicrobial preservatives. However, sodium pentachlorophenate produces an immediate increase in viscosity when added to hydroxyethyl cellulose solutions.
Hydroxyethyl cellulose has good tolerance for dissolved electrolytes, although it may be salted out of solution when mixed with certain salt solutions. For example, the following salt solutions will precipitate a 10% w/v solution of Cellosize WP-09 and a 2% w/v solution of Cellosize WP-4400: sodium carbonate 50% and saturated solutions of aluminum sulfate; ammonium sulfate; chromic sulfate; disodium phosphate; magnesium sulfate; potassium ferrocyanide; sodium sulfate; sodium sulfite; sodium thiosulfate; and zinc sulfate.
Natrosol is soluble in most 10% salt solutions, excluding sodium carbonate and sodium sulfate, and many 50% salt solutions with the exception of the following: aluminum sulfate; ammonium sulfate; diammonium phosphate; disodium phosphate; ferric chloride; magnesium sulfate; potassium ferrocyanide; sodium metaborate; sodium nitrate; sodium sulfite; trisodium phosphate; and zinc sulfate. Natrosol 150 is generally more tolerant of dissolved salts than is Natrosol 250.
Hydroxyethyl cellulose is also incompatible with certain fluorescent dyes or optical brighteners, and certain quaternary disinfectants which will increase the viscosity of aqueous solutions.
Regulatory Status
Included in the FDA Inactive Ingredients Database (ophthalmic preparations; oral syrups and tablets; otic and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Hydroxyethyl cellulose is not currently approved for use in food products in Europe or the USA, although it is permitted for use in indirect applications such as packaging. This restriction is due to the high levels of ethylene glycol residues that are formed during the manufacturing process.

Hydroxyethyl Cellulose Upstream-Materialien And Downstream Produkte

Hydroxyethyl Cellulose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

9004-62-0, Hydroxyethyl Cellulose Verwandte Suche:

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