5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridiniumchlorid

Bezeichnung:5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridiniumchlorid

CAS-Nr53885-35-1

Englisch Name:Ticlopidine hydrochloride

CBNumberCB0674371

SummenformelC14H14ClNS.ClH

Molgewicht300.25

MOL-Datei53885-35-1.mol

Synonyma

5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridiniumchlorid

5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridiniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	205°C
Dichte	1.37 g/cm3
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate.
Aggregatzustand	Solid
pka	7.64(at 25℃)
Farbe	White
Wasserlöslichkeit	Soluble to 100 mM in water and to 100 mM in DMSO.
maximale Wellenlänge (λmax)	295nm(H2O)(lit.)
Merck	14,9421
CAS Datenbank	53885-35-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	36-37/39-26
WGK Germany	3
RTECS-Nr.	XJ9089100
HS Code	2934990002
Toxizität	LD50 in mice (mg/kg/24 hrs): 55 i.v.; >300 orally (Castaigne)

Gefahreninformationscode (GHS)

Ticlopidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White Solid
Originator
Ticlid,Millot,France,1978
Verwenden
An antithrombotic. a platelet aggregation inhibitor
Verwenden
mucolytic, antibacterial, surface active agent
Verwenden
Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. It inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.
Manufacturing Process
A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours. After evaporation of the solvent, the solid residue consists of 5-(2- chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C (derivative n° 30). This compound is taken up into a solution comprising ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is added portionwise to the solution maintained at room temperature. The reaction medium is maintained under constant stirring during 12 hours and is then evaporated. The residue is taken up into water and made acidic with concentrated hydrochloric acid to destroy the excess reducing agent. The mixture is then made alkaline with ammonia and extracted with ether. The ether solution is washed with water, dried and evaporated. The oily residue is dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2- chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals (yield: 60%) having a melting point (Koefler block) of 190°C.
Therapeutic Function
Platelet aggregation inhibitor
Biologische Aktivität
Selective P2Y 12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo .

Ticlopidine hydrochloride Upstream-Materialien And Downstream Produkte

5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridiniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

53885-35-1, Ticlopidine hydrochloride Verwandte Suche:

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