Cefaloridin

Bezeichnung:Cefaloridin

CAS-Nr50-59-9

Englisch Name:Cephaloridine

CBNumberCB4875354

SummenformelC19H17N3O4S2

Molgewicht415.48

MOL-Datei50-59-9.mol

Synonyma

Cefaloridin

Cefaloridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	184°C
alpha	D +47.7° (c = 1.25 in water)
Dichte	1.3230 (rough estimate)
Brechungsindex	1.6390 (estimate)
storage temp.	2-8°C
pka	3.2(at 25℃)
Optische Rotation	+47.720 (c 1.25, H2O)
Wasserlöslichkeit	>20g/L(21 ºC)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	42/43
S-Sätze:	22-36/37-45
Giftige Stoffe Daten	50-59-9(Hazardous Substances Data)
Toxizität	LD50 mice, rats (g/kg): >15, 2.5-4 orally; in monkeys (g/kg): >0.2 i.m. (Atkinson)

Gefahreninformationscode (GHS)

Cephaloridine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
This was derived by adding two side chains to the nucleus of cephalothin, and has the formula 7-(2-thienyl acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine (Muggleton et al., 1964). Cephaloridine was initially widely used, but it had two main disadvantages. It was an unreliable antistaphylococcal drug, as it was relatively easily hydrolyzed by Staphylococcus aureus beta-lactamase (Laverdiere et al., 1978; Sabath, 1989). Second, cephaloridine was nephrotoxic (Foord, 1975; Appel and Neu, 1977). Marketing of the drug was discontinued in the USA in December 1980. Nowadays, this drug is used very rarely, if at all.
Originator
Ceporin,Glaxo,UK,1964
Verwenden
Antibacterial agent.
Definition
ChEBI: A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.
Manufacturing Process
7-Aminocephalosporanic acid (5.00 g) which passed through a 100-mesh sieve was suspended in boiling ethyl acetate (200 ml), and 2-thienylacetyl chloride (Cagniant, Bull. Soc. Chim. France, 1949, 847) (4.42 g, 1.5 equiv.) was added in ethyl acetate (20 ml). The mixture was boiled under reflux for 40 minutes, cooled, and filtered. Aniline (5.03 ml) was added, and after 1 hour the mixture was extracted with 3% sodium hydrogen carbonate solution (1 x 150 ml, 2 x 100 ml, 1 x 50 ml) and the alkaline extracts washed with ethyl acetate (3 x 100 ml). The aqueous solution was acidified to pH 1.2, and extracted with ethyl acetate (2 x 150 ml). The ethyl acetate extract was washed with water (4 x 40 ml), dried (MgSO4), and concentrated in vacuo to low volume. The crude 7-2'-thienylacetamidocephalosporanic acid (2.5 g) which separated was collected by filtration. Evaporation of the filtrate gave a further 2.68 g (71%) of the product, which was purified by crystallization from ethyl acetate, then aqueous acetone, MP 150°C to 157°C (decomp.).
7-2'-Thienylacetamidocephalosporanic acid (7.0 g) was suspended in water (60 ml) and stirred with pyridine (7 ml) until the acid dissolved. The resulting solution (pH 5.9) was kept at 35°C for 3 days, then filtered and extracted with methylene chloride (4 x 60 ml). The methylene chloride extract was back-extracted with a little water and the total aqueous solutions were then percolated through a column of Dowex 1 x 8 resin, (100 to 200 mesh, 150 g) in the acetate form at pH 4.3. The column was washed with water until the optical rotation of the eluate fell to zero and the eluate (500 ml) was freeze-dried. The residual white solid was dissolved in the minimum volume of methanol and after a few minutes the pyridine derivative crystallized; this is the cephaloridine product.
Trademarks
Kefloridin (Lilly); Loridine (Lilly);Cepalorin;Faredina;Latorex;Lauridin.
Therapeutic Function
Antibacterial
Weltgesundheitsorganisation (WHO)
Cefaloridine, a semi-synthetic cephalosporin antibiotic, was introduced into medicine in 1964 for the treatment of bacterial infections. It is considered to be the most toxic of the cephalosporins, and for this reason is now seldom used. Nevertheless, it still remains available in certain countries and the World Health Organization is not aware of restrictive actions taken elsewhere.
Allgemeine Beschreibung
Cephaloridine, along with cephalothin, was the first member of the synthetic cephalosporin C class of antibiotic, to be introduced clinically. It was synthesized, starting with 7-aminocephalosporanic acid, by Glaxo Research Laboratories in 1962. This drug shows strong activity against gram-positive and gramnegative bacteria and Leptospira, including benzylpenicillin-resistant strains. It has been given widely by intravenous, intramuscular, and intraspinal injection to treat a variety of infections caused by Staphylococcus, Streptococcus, Neisseria, Klebsiella, Escherichia coli, and other pathogens. Because of its renal toxicity and the development of newer and more active synthetic cephalosporins, its use is declining.
Hazard
Moderately to very toxic.

Cephaloridine Upstream-Materialien And Downstream Produkte

Cefaloridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50-59-9, Cephaloridine Verwandte Suche:

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