Propylamin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H290：Kann gegenüber Metallen korrosiv sein.

  H302：Gesundheitsschädlich bei Verschlucken.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P330+P331：BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

Propylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE, HYGROSKOPISCHE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger Rauche (Stickstoffoxide). Mittelstarke Base, reagiert mit Säuren und greift Aluminium und Zink an. Reagiert sehr heftig mit Oxidationsmitteln und Quecksilberunter Feuer- und Explosionsgefahr. Reagiert sehr heftig mit vielen Verbindungen wie halogenierte Kohlenwasserstoffe, Alkohole und einige Nitroparaffine. Greift Kupfer und Kupferlegierungen an.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz verätzt die Augen, die Haut und die Atemwege.

• LECKAGE

  Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Zündquellen entfernen. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Verschüttete Flüssigkeit mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R34:Verursacht Verätzungen.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  n-Propylamine, also known as propylamine, is a colorless liquid with a pungent odor resembling ammonia. It has strong basic properties, leading to its easy formation of salts when combined with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961).
  

• Verwenden

  n-Propylamine is used as an intermediate inmany organic reactions. It has been used in the synthesis of single crystals of siliceous ferrierite.

• Verwenden

  1-Propylamine is used in chemical analysis and to make other chemicals, used as a solvent in organic synthesis. And it is used as finishing agent of drugs, paints, rubber, fiber, textile and resin. Additionally, it can be used as petroleum additive and preservative.

• Vorbereitung Methode

  There are several methods employed in the manufacture of propylamine. Typically, ammonia and propanol are reacted over a dehydration catalyst at high temperature and pressure. Ammonia, propanol, and hydrogen can also be reacted over a dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer et al 1978).

• Definition

  ChEBI: Propylamine is a member of the class of alkylamines that is propane substituted by an amino group at C-1. It is a conjugate base of a propan-1-aminium.

• Aroma threshold values

  High strength odor; ammoniacal type; recommend smelling in a 0.10% solution or less.

• Allgemeine Beschreibung

  A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.

• Air & Water Reaktionen

  Highly flammable. Slightly soluble in water.

• Reaktivität anzeigen

  Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Propylamine emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].

• Hazard

  Highly flammable, dangerous fire risk, explosive limits in air 2–10%, use alcohol foam to extinguish. Strong irritant to skin and tissue.

• Health Hazard

  n-Propylamine is a strong irritant and a mod erately toxic substance. the toxic routes areinhalation, ingestion, and absorption throughthe skin. Contact of the liquid on the skincan cause burns and possibly skin sensitization. Irritation in the eyes from exposure tohigh concentrations can be severe. It is a respiratory tract irritant, similar to ethylamine.Inhalation of 2300 ppm of n-propylamine for4 hours caused labored breathing, hepatitis,and hepatocellular necrosis in rats. It is somewhat less toxic than ethylamine by oral anddermal routes.
  LC50 value, inhalation (mice): 2500 mg/m³/2 hr
  
  LD50 value, oral (rats): 570 mg/kg
  LD50 value, skin (rabbits): 560 mg/kg.

• Brandgefahr

  Highly flammable liquid; flash point (closed cup) -37°C (-35°F); vapor density 2.0 (air = 1), vapor can travel a considerable distance to a source of ignition and flash back; autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or “alcohol” foam; water should be used to keep fire-exposed containers cool and to flush and dilute the spill.
  n-Propylamine forms explosive mixtures in air; LEL and UEL values are 2.0% and 10.4% by volume in air, respectively. There is no report of explosion associated with this compound. It is expected to exhibit violent reactions characteristic of lower aliphatic primary amines .

• Industrielle Verwendung

  Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs, propyl isocyanate, textile and leather finishing resins and corrosion inhibitors. It is also used in the production of pharmaceuticals such as Prilocaine, pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of propylamine were manufactured in the U.S. (HSDB 1988).

• Sicherheitsprofil

  Moderately toxic by inhalation, ingestion, and skin contact routes. A skin and severe eye irritant. Possibly a skin sensitizer. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. Incompatible with triethynyl aluminum. See also AMINES.

• mögliche Exposition

  Propylamine is used to make textile resins, drugs, pesticides, and other chemicals.

• Stoffwechsel

  To date, there are several studies which indicate that propylamine may be metabolized in many animal species, including man. When propylamine hydrochloride was administered to humans orally, little of the parent compound was recovered in the urine (Rechenberger 1940). It has also been reported that dogs are capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966) demonstrated that monoamine oxidase, purified from rabbit serum, was capable of oxidizing propylamine, although less actively than substituted phenylethylamines such as dopamine. Further characterization revealed that the protonated amine is bound by an unprotonated enzyme group, that the enzyme active site is composed of hydrophobic residues, and that interaction of the amine residues determines maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of the amine could be stimulated by the presence of aliphatic alcohols which apparently bond in a tertiary complex with the enzyme and substrate, thereby increasing the effectiveness of substrate binding.
  Other investigators have provided evidence that propylamine may not be a substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974). Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not metabolize propylamine.

• Versand/Shipping

  UN1277 Propylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.

• läuterung methode

  Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.]

• Inkompatibilitäten

  Propylamine Vapors may form explosive mixture with air. Violent reaction on contact with oxidizers and mercury, strong acids; organic anhydrides; isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons; alcohols and many other compounds. Attacks many metals and alloys, especially those of copper. Aqueous solution is acidic and may attack glass.

• Filter für giftige stoffe

  The initial threshold screening level (ITSL) for propylarnine is 112 μg/m3 based on anannual averaging time.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Propylamine Upstream-Materialien And Downstream Produkte

Propylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(404)Suppliers

107-10-8, Propylamine Verwandte Suche: