1-Aminocyclopentancarbonsäure

Bezeichnung:1-Aminocyclopentancarbonsäure

CAS-Nr52-52-8

Englisch Name:Cycloleucine

CBNumberCB7376009

SummenformelC6H11NO2

Molgewicht129.16

MOL-Datei52-52-8.mol

Synonyma

1-Aminocyclopentan-1-carbonsure

1-Aminocyclopentancarbonsäure

1-Aminocyclopentancarbonsäure physikalisch-chemischer Eigenschaften

Schmelzpunkt	320 °C (dec.) (lit.)
Siedepunkt	239.22°C (rough estimate)
Dichte	1.1426 (rough estimate)
Brechungsindex	1.4827 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
Aggregatzustand	Crystalline Flakes or Powder
pka	2.38±0.20(Predicted)
Farbe	White to beige
Wasserlöslichkeit	5 g/100 mL
Merck	14,2734
BRN	636626
CAS Datenbank	52-52-8(CAS DataBase Reference)
NIST chemische Informationen	Cyclopentanecarboxylic acid, 1-amino-(52-52-8)
EPA chemische Informationen	Cyclopentanecarboxylic acid, 1-amino- (52-52-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22
S-Sätze:	22-24/25
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	GY2625000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29224999
Giftige Stoffe Daten	52-52-8(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 290mg/kg

Gefahreninformationscode (GHS)

Cycloleucine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER
Verwenden
Cycloleucine can be used as a building block to synthesize:
- Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction.
- Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist.
Verwenden
Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies
Verwenden
NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist
Definition
ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.
Allgemeine Beschreibung
Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.
läuterung methode
Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]

Cycloleucine Upstream-Materialien And Downstream Produkte

1-Aminocyclopentancarbonsäure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

52-52-8, Cycloleucine Verwandte Suche:

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