Tiamulin fumarate

Bezeichnung:Tiamulin fumarate

CAS-Nr55297-96-6

Englisch Name:Tiamulin fumarate

CBNumberCB0294038

SummenformelC32H51NO8S

Molgewicht609.82

MOL-Datei55297-96-6.mol

Tiamulin fumarate physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-148°C
Siedepunkt	563℃
Flammpunkt	>110°(230°F)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	Soluble in water
Merck	13,9495
InChIKey	YXQXDXAHCSEVSD-IHAONTCTSA-N
SMILES	C(/C(=O)O)=C\C(=O)O.C[C@H]1[C@@H]([C@](C[C@@H](OC(=O)CSCCN(CC)CC)C2([C@H](C)CCC31CCC(=O)[C@]32[H])C)(C)C=C)O \|&1:9,10,11,13,27,36,r\|
CAS Datenbank	55297-96-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
RIDADR	UN2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	AG9560000
HS Code	29419090

Gefahreninformationscode (GHS)

Tiamulin fumarate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide.
Verwenden
Tiamulin fumarate is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis. It is a derivative of Pleuromutilin with Antibacterial that targets Gram-positive bacteria as well as a few mycoplasma species.
Application
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.
Indications
Tiamulin fumarate is mainly used for Mycoplasma suis pneumonia, Haemophilus parasuis, infectious pleuropneumonia and dysentery caused by Treponema swine, and also for chronic respiratory tract of poultry, Mycoplasma pneumonia, infectious rhinitis, Escherichia coli, duck Infectious serositis.
Health Hazard
Inhalation may irritate (cough, short breathing, difficulty in breathing). Headache. It may cause moderate irritation, including a burning sensation, tearing, redness, or swelling. Itching. Causes serious eye irritation. Redness, itching, tears. Stinging. It may cause irritation to the digestive tract. Abdominal pain, nausea.
Mode of action
Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, which inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.

Tiamulin fumarate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

55297-96-6, Tiamulin fumarate Verwandte Suche:

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