Tiamulin

Bezeichnung:Tiamulin

CAS-Nr55297-95-5

Englisch Name:Tiamulin

CBNumberCB7171536

SummenformelC28H47NO4S

Molgewicht493.74

MOL-Datei55297-95-5.mol

Tiamulin physikalisch-chemischer Eigenschaften

Schmelzpunkt	147.5°C
Siedepunkt	563.0±50.0 °C(Predicted)
Dichte	1.0160 (rough estimate)
Brechungsindex	1.6550 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	14.65±0.70(Predicted)
Aggregatzustand	Oil
Farbe	Colourless
CAS Datenbank	55297-95-5(CAS DataBase Reference)
EPA chemische Informationen	Tiamulin (55297-95-5)

Sicherheit

WGK Germany	2
RTECS-Nr.	AG9552000
HS Code	2941906000
Giftige Stoffe Daten	55297-95-5(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Tiamulin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Tiamulin is a derivative of Pleuromutilin. Antibacterial.
Verwenden
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.
Definition
ChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo the treatment of swine dysentery caused by Serpulina hyodysenteriae.
Allgemeine Beschreibung
Tiamulin has been developed by that company in collaboration with E.R. Squibb & Sons for use against animal infec tions. Tiamulin is used against dysentery and Mycoplasma infections in sheep, swine, cattle, and chickens.
Sicherheitsprofil
Poison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.
Synthese
Tiamulin was synthesized by Sandoz Co. in 1973, starting from pleuromutilin produced by Pleurotus mutilus.
Veterinary Drugs and Treatments
Tiamulin is approved for use in swine to treat pneumonia caused by susceptible strains of Haemophilus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed additive, it is used to cause increased weight gain in swine.

Tiamulin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

55297-95-5, Tiamulin Verwandte Suche:

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