Pleuromulin

Bezeichnung:Pleuromulin

CAS-Nr125-65-5

Englisch Name:Pleuromulin

CBNumberCB4436641

SummenformelC22H34O5

Molgewicht378.5

MOL-Datei125-65-5.mol

Synonyma

Pleuromulin

Pleuromulin physikalisch-chemischer Eigenschaften

Schmelzpunkt	170-1710C
alpha	D24 +20° (c = 3 in abs ethanol)
Siedepunkt	482.8±45.0 °C(Predicted)
Dichte	1.15±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
Löslichkeit	DMSO: >10mg/mL (warmed)
Aggregatzustand	powder
pka	12.91±0.10(Predicted)
Farbe	white to beige
Optische Aktivität	[α]/D +30 to +40° (c=1; CH2Cl2)
InChIKey	YSBXUHAJXRCCET-BKUNHTPHSA-N

Sicherheit

WGK Germany	3
RTECS-Nr.	MC5408000
Toxizität	LD50 in mice: >60 mg/kg (Kavanagh, 1952)

Gefahreninformationscode (GHS)

Pleuromulin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Pleuromutilin is an antibiotic derived from the fungus Clitopilus that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.
Chemische Eigenschaften
Pleuromulin is Crystalline Solid
Verwenden
Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.
Verwenden
Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.
Einzelnachweise
[1]. kilaru s, collins cm, hartley aj, et al. establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus clitopilus passeckerianus. appl environ microbiol. 2009 nov;75(22):7196-204.
[2]. long ks, hansen lh, jakobsen l, et al. interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. antimicrob agents chemother. 2006 apr;50(4):1458-62.

Pleuromulin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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