盐酸多巴酚丁胺

概述生物活性体内研究盐酸多巴酚丁胺试剂级价格

盐酸多巴酚丁胺

CAS号:49745-95-1
英文名:Dobutamine hydrochloride
中文名:盐酸多巴酚丁胺
CBNumber:CB8274063
分子式:C18H24ClNO3
分子量:337.84
MOL File:49745-95-1.mol

盐酸多巴酚丁胺化学性质

熔点 :184-186 C
储存条件 :2-8°C
溶解度 :Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
形态 :Solid
酸度系数(pKa) :9.45(at 25℃)
颜色 :White to Off-White
水溶解性 :Soluble in water or ethanol with warming. Also soluble in methanol
最大波长(λmax) :281nm(MeOH)(lit.)
Merck :14,3395
稳定性 :Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
InChI :InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChIKey :BQKADKWNRWCIJL-UHFFFAOYSA-N
SMILES :C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
CAS 数据库 :49745-95-1(CAS DataBase Reference)
EPA化学物质信息 :1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)

安全信息

危险品标志 :Xn,Xi
危险类别码 :20/21/22-63-36/37/38-R63-R62-R11-R21-R20
安全说明 :22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
WGK Germany :3
海关编码 :29222990
毒性 :LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)

盐酸多巴酚丁胺性质、用途与生产工艺

概述盐酸多巴酚丁胺，又称杜丁胺，是多巴胺的同系物，临床用于心排血量低和心率慢的心力衰竭，其改善左心室功能的作用优于多巴胺。化学性质较不稳定，空气、光线、热、微量的铜、铁等金属及pH均能使其降解、氧化、破坏。
生物活性 Dobutamine hydrochloride 是合成的儿茶酚胺，作用于肾上腺素能受体 α1-AR, β1-AR 和 β2-AR。Dobutamine hydrochloride 是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。Dobutamine hydrochloride 可增加心输出量，矫正低灌注。

体内研究

Dobutamine hydrochloride has a rapid onset of action and a short half-life .
Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.
Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.
Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.
Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.
Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.

Animal Model:	Tgαq*44 mice (heart failure models)
Dosage:	0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:	Intraperitoneal injection
Result:	Induced different response in cardiac function on a low and high dose in mice with with heart failure.