盐酸多巴酚丁胺
盐酸多巴酚丁胺 性质
| 熔点 | 184-186 C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 微溶于水，溶于甲醇，微溶于乙醇（96%）。 |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.45(at 25℃) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water or ethanol with warming. Also soluble in methanol |
| 最大波长(λmax) | 281nm(MeOH)(lit.) |
| Merck | 14,3395 |
| 稳定性 | 溶液在 pH 11-13 时会迅速氧化。建议新鲜配制溶液并避光。盐酸多巴酚丁胺对光敏感。 |
| InChI | InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H |
| InChIKey | BQKADKWNRWCIJL-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl |
| CAS 数据库 | 49745-95-1(CAS DataBase Reference) |
| EPA化学物质信息 | 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1) |
盐酸多巴酚丁胺 用途与合成方法
Dobutamine hydrochloride has a rapid onset of action and a short half-life .
Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.
Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.
Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.
Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.
Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.
| Animal Model: | Tgαq*44 mice (heart failure models) |
| Dosage: | 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose |
| Administration: | Intraperitoneal injection |
| Result: | Induced different response in cardiac function on a low and high dose in mice with with heart failure. |
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 20/21/22-63-36/37/38-R63-R62-R11-R21-R20 |
| 安全说明 | 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22 |
| WGK Germany | 3 |
| 海关编码 | 29222990 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经皮 急性毒性 类别4 吸入 急性毒性 类别4 经口 生殖毒性 类别2 |
| 毒性 | LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle) |
盐酸多巴酚丁胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-15746 | 盐酸多巴酚丁胺 | 49745-95-1 | 10 mg | 336 |
| 2025-12-22 | HY-15746 | 盐酸多巴酚丁胺 | 49745-95-1 | 10mM * 1mLin DMSO | 369 |
