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999-97-3

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Material Safety Data Sheet(MSDS) Questions and Answers (Q&A) Questions And Answer Spectrum Detail Well-known Reagent Company Product Information

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Identification

Name
Hexamethyldisilazane
CAS
999-97-3
Synonyms
1,1,1,3,3,3-HEXAMETHYLDISILAZANE
1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
BIS(TRIMETHYLSILYL)AMINE
HEXAMETHYLDISILAZANE
hexamethyl disilizane
HEXAMETHYLDISILYLAMINE
HMDS
LABOTEST-BB LT01408762
SILAZANE HMN
((CH3)3Si)2NH
1,1,1,3,3,3-hexamethyl-disilazan
1,1,1-trimethyl-n-(trimethylsilyl)-silanamin
Disilazane, 1,1,1,3,3,3-hexamethyl-
hexamethyldisilazane(hmds)
hexamethylsilazane
sz6079
Trimethyl-N-(trimethylsilyl)silanamine
tsl8802
1,1,1,3,3,3-Hexamithyl disilazane
(dimethyl-trimethylsilylamino-silyl)methane
EINECS(EC#)
213-668-5
Molecular Formula
C6H19NSi2
MDL Number
MFCD00008259
Molecular Weight
161.39
MOL File
999-97-3.mol

Chemical Properties

Appearance
Colorless liquid
mp 
-78 °C
bp 
125 °C(lit.)

density 
0.774 g/mL at 25 °C(lit.)

refractive index 
n20/D 1.407(lit.)

Fp 
57.2 °F

storage temp. 
2-8°C

Water Solubility 
REACTS
Sensitive 
Moisture Sensitive
Merck 
14,4689
BRN 
635752
CAS DataBase Reference
999-97-3(CAS DataBase Reference)
NIST Chemistry Reference
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-(999-97-3)
Storage Precautions
Store under nitrogen;Moisture sensitive
EPA Substance Registry System
999-97-3(EPA Substance)

Safety Data

Hazard Codes 
F,C,Xn
Risk Statements 
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
Safety Statements 
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 3286 3/PG 2

WGK Germany 
2

RTECS 
JM9230000


21
Hazard Note 
Flammable
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29319099
Hazardous Substances Data
999-97-3(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A liquid. Boiling point of 260°F. Flash point 77°F. May be toxic by ingestion. Irritates skin and eyes. Vapors are heavier than air. May emit highly toxic nitrogen oxide fumes when heated to decomposition. Used to make other chemicals.
Reactivity Profile
HEXAMETHYL DISILAZANE(999-97-3) reacts with many carbonyl containing organic compounds to generate gaseous ammonia. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Highly flammable. Moisture sensitive.
Hazard
Flammable, moderate fire risk.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Material Safety Data Sheet(MSDS)

Questions and Answers (Q&A)

Description
Hexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can be used for silanizing the surface of silicon water, cellulose. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). The hexamethyldisilazane coatings on various nanoparticles make them be resistant to water contamination and flocculation during synthesis. It can also be used as a modifier to control the shape, formation of agglomerates surface area and pore size of silica particles. Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.
References
Deng, Xiang. "Hexamethyldisilazane." Synlett 2011.06(2011):881-882. Chiavari, G, D. Fabbri, and S. Prati. "Gas chromatographic-mass spectrometric analysis of products arising from pyrolysis of amino acids in the presence of hexamethyldisilazane." Journal of Chromatography A922.1–2(2001):235-241.
Nation, J. L. "A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy." Stain Technology 58.6(1983):347-51.
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Questions And Answer

Reaction
Hexamethyldisilazane(HMDS) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.One of the advantages of Hexamethyldisilazane over chlorosilanes is that no base is needed as a hydrochloric acid acceptor. It produces ammonia which escapes easily from the reaction mixture during silylation.

Spectrum Detail

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