6-Chloro-1H-pyrrolo[2,3-b]pyridine

849068-50-4

55052-27-2

Example 96 Step C: Synthesis of 6-chloro-1H-pyrrolo[2,3-B]pyridine. Ethyl 6-chloro-pyrrolo[2,3-B]pyridine-1-carboxylate (400 mg, 1.78 mmol) was dissolved in methanol (35 mL), followed by the addition of 1N sodium hydroxide solution (13 mL). The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was neutralized with saturated sodium bicarbonate solution and the precipitate was collected by filtration. The precipitate was washed with water and dried by vacuum pump to afford the target product 6-chloro-1H-pyrrolo[2,3-B]pyridine (260 mg, 1.71 mmol, 96% yield). MS (electrospray positive ion mode): m/e = 153.1 ([M+H]+); LC retention time: 2.85 min.