6-Bromo-1H-pyrrolo[2,3-b]pyridine

143468-12-6

143468-13-7

Step 2: To a solution of 1-benzoyl-6-bromo-1H-pyrrolo[2,3-b]pyridine (0.046 g, 0.15 mmol) in methanol (5.0 mL) was added 5 N aqueous sodium hydroxide solution (1.0 mL). The reaction mixture was stirred at room temperature for 2 hours. After the reaction was completed, the solvent was removed by concentration under reduced pressure. The residue was extracted with ether (3 × 10 mL) and the organic layers were combined and washed sequentially with water (10 mL) and saturated sodium chloride solution (10 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6-bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 95% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.01 (d, J = 8.1 Hz, 1H), 7.46 (d, J = 8.1 Hz, 1H), 7.75 (d, J = 8.1 Hz, 1H), 8.51 (d, J = 8.1 Hz, 1H).