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872-50-4

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Identification

Name
1-Methyl-2-pyrrolidinone
CAS
872-50-4
Synonyms
1-METHYL-2-PYRROLIDINONE
1-METHYL-2-PYRROLIDONE
M-PYROL(R)
N-METHYL-2-KETOPYRROLIDINE
N-METHYL-2-PYROLLIDONE
N-METHYL-2-PYRROLIDINONE
N-METHYL-2-PYRROLIDONE
N-METHYLPYROLIDONE
N-METHYLPYRROLID-2-ONE
N-METHYLPYRROLIDINONE
N-METHYLPYRROLIDNONE
N-METHYLPYRROLIDONE
NMP
NMP-EL
NMP-T
0131
1-methyl-2-pyrrolidinon
1-Methyl-5-pyrrolidinone
1-Methylazacyclopentan-2-one
1-Methylazacyclopentane-2-one
EINECS(EC#)
212-828-1
Molecular Formula
C5H9NO
MDL Number
MFCD00003193
Molecular Weight
99.13
MOL File
872-50-4.mol

Chemical Properties

Appearance
colourless or light yellow liquid with an amine odour
Melting point 
−24 °C(lit.)

mp 
−24 °C(lit.)

Boiling point 
202 °C(lit.)

bp 
202 °C(lit.)

density 
1.028 g/mL at 25 °C(lit.)

vapor density 
3.4 (vs air)

vapor pressure 
0.29 mm Hg ( 20 °C)

refractive index 
n20/D 1.479

Fp 
187 °F

storage temp. 
2-8°C

solubility 
ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form 
Liquid
color 
≤20(APHA)

PH
8.5-10.0 (100g/l, H2O, 20℃)
Stability:
Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.
explosive limit
1.3-9.5%(V)
Water Solubility 
>=10 g/100 mL at 20 ºC
λmax
283nm(MeOH)(lit.)
Sensitive 
Hygroscopic
Detection Methods
GC
Merck 
14,6117
BRN 
106420
InChIKey
SECXISVLQFMRJM-UHFFFAOYSA-N
Contact allergens
1-Methylpyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but it can cause severe contact dermatitis due to prolonged contact.
CAS DataBase Reference
872-50-4(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyrrolidinone, 1-methyl-(872-50-4)
Storage Precautions
Store under nitrogen;Moisture sensitive
EPA Substance Registry System
872-50-4(EPA Substance)

Hazard Information

Definition
ChEBI: A member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
General Description
A clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199°F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion.
Reactivity Profile
This amine is a very mild chemical base. N-METHYL-2-PYRROLIDONE(872-50-4) does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Soluble in water.
Hazard
Severe skin and eye irritant. Explosive lim-its 2.2–12.2%.
Health Hazard
Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation.
Fire Hazard
Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire.

Safety Data

Hazard Codes 
T,Xi
Risk Statements 
R45:May cause cancer.
R65:Harmful: May cause lung damage if swallowed.
R36/38:Irritating to eyes and skin .
Safety Statements 
S41:In case of fire and/or explosion do not breathe fumes .
RIDADR 
UN 1268 3/PG 3

WGK Germany 
1

RTECS 
UY5790000


3-8-10
TSCA 
Y
HS Code 
29339900
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Combustible when exposed to heat, open flame, or powerful oxidizers. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data
872-50-4(Hazardous Substances Data)

Raw materials And Preparation Products

Questions And Answer

Chemical Properties
1-Methyl-2-pyrrolidinone (NMP) has a molecular formula of C5H9NO, and it is a colorless to light yellow transparent liquid with a slight ammonia odor. Its boiling point is 204℃, flash point is 91℃, chroma HaZen≤25, refractive index N20D 1.468-1.471, density is 1.032-1.035. It is miscible in water at any ratio, it is soluble in ethanol, acetone, esters, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents, and it can completely mix with practically all solvents. It is strongly hygroscopic, chemically stable, not corrosive towards carbon steel and aluminum, and slightly corrosive to copper. It has low adhesiveness, strong chemical and thermal stability, high polarity, and low volatility. This product is slightly toxic, and its permitted concentration limit in air is 100PPM.
Uses
  1. 1-Methyl-2-pyrrolidinone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability. It is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins.
  2. It is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits.
  3. It can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.
  4. 1-Methyl-2-pyrrolidinone is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization.
  5. It is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization.
  6. It can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent.
  7. It is used in mediums for polymerization reactions such as engineering plastics and aramid fiber.
  8. 1-Methyl-2-pyrrolidinone is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries.
  9. high purity grade for ICP-MS detection.
  10. For peptide synthesis.

toxicity

Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg.


Waste Disposal
Consult state, local or national regulations for proper disposal. Disposal must be made according to official regulations. Water, if necessary with cleansing agents.
storage
NMP is hygroscopic (picks up moisture) but stable under normal conditions. It will violently react with strong oxidizers such as hydrogen peroxide, nitric acid, sulfuric acid, etc. The primary decomposition products produce carbon monoxide and nitrogen oxide fumes. Excessive exposure or spillage should be avoided as a matter of good practice. Lyondell Chemical Company recommends wearing butyl gloves when using NMP. NMP should be stored in clean, phenolic-lined mild steel or alloy drums. Teflon®1 and Kalrez®1 have been shown to be suitable gasket materials. Please review MSDS prior to handling.

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